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Table 4 Capacity of the (H6-ED3-PhoA) 2 reagents to discriminate between DENV-infected and DENV-uninfected serums in a MAC-ELISA

From: Cross-reactivities between human IgMs and the four serotypes of dengue virus as probed with artificial homodimers of domain-III from the envelope proteins

(+) Serums R1 R2 R3 R4
DENV1 0.94 ± 0.05 0.83 ± 0.06 0.64 ± 0.08 0.59 ± 0.08
DENV2 0.90 ± 0.03 0.88 ± 0.05 0.57 ± 0.06 0.42 ± 0.07
DENV3 0.82 ± 0.06 0.75 ± 0.07 0.77 ± 0.07 0.18 ± 0.08
DENV4 0.73 ± 0.05 0.55 ± 0.06 0.45 ± 0.06 0.61 ± 0.07
DENV1-4 0.83 ± 0.03 0.73 ± 0.04 0.59 ± 0.04 0.47 ± 0.04
  1. R1 to R4, (H6-ED3-PhoA)2 dimers of serotypes DENV1 to DENV4, respectively. The first column gives the serotype of the infecting DENV for the (+) serums. DENV1-4, the serotype of the infecting virus could be any one of DENV1 to DENV4. The DENV-uninfected serums were always taken as (−) serums. Each entry gives the accuracy and associated standard error of a MAC-ELISA that used the Ri reagent (i = 1, …, 4) as an antigen and was evaluated on the (+) and (−) serums.