Table 2 Changes in immuno-virological, haematological and metabolic markers, anthropometric and body composition parameters, and in bone markers as a function of treatment time

CD4 lymphocytes /ml

240 (153)

376 (158)

497 (189)

0.001

241 (131)

445 (167)

493 (127)

0.001

0.54

Viral load, log10/ml

5.05 (0.85)

2.08 (0.85)

1.62 (0.07)

0.001

5.04 (0.55)

1.91 (0.88)

1.59 (0.01)

0.001

0.99

Cholesterol, g/l

1.88 (0.45)

2.22 (0.66)

2.29 (0.41)

0.001

1.61 (0.34)

1.95 (0.46)

2.03 (0.41)

0.001

0.99

HDL-cholesterol, g/l

0.44 (0.08)

0.45 (0.10)

0.52 (0.15)

0.06

0.38 (0.10)

0.52 (0.16)

0.56 (0.16)

0.001

0.003

Triglycerides, g/l

1.14 (0.58)

1.99 (1.68)

1.75 (0.82)

0.002

0.99 (0.48)

1.34 (1.64)

1.31 (0.97)

0.26

0.06

Glucose, g/l

0.84 (0.08)

0.88 (0.08)

0.87 (0.07)

0.14

0.83 (0.09)

0.94 (0.08)

0.90 (0.07)

0.001

0.08

Lactate, mmoles/l

0.93 (0.28)

1.06 (0.39)

1.11 (0.44)

0.24

0.98 (0.28)

0.94 (0.24)

0.93 (0.35)

0.68

0.19

Albumin, g/l

39.0 (4.9)

42.6 (2.0)

42.5 (2.0)

0.006

41.7 (3.7)

43.1 (3.5)

42.9 (2.5)

0.07

0.05

Cockroft (ml/min)

83.9

82.9

86.1

0.73

102.3

103.1

104

0.66

0.97

Waist circumference, cm

83.2 (11.3)

87.5 (16.7)

89.7 (13.7)

0.04

82.3 (7.4)

82.5 (8.3)

81.9 (9.1)

0.51

0.03

BMI, kg/m2

23.6 (3.6)

25.0 (4.9)

25.7 (5.5)

0.02

23.9 (3.6)

24.0 (3.7)

24.3 (3.7)

0.73

0.03

Body Mineral content, kg

3.02 (0.69)

2.97 (0.63)

2.93 (0.58)

0.06

3.11 (0.56)

3.08 (0.57)

3.04 (0.53)

0.008

0.58

L2-L4 BMD, g/cm2

1.234

1.182 (0.226)

1.186 (0.238)

0.001

1.249 (0.178)

1.232 (0.196)

1.230

0.04

0.05

(0.234)

(0.176)

Body lean mass, kg

46.3 (8.8)

48.2 (10.9)

48.9 (11.2)

0.05

49.4 (10.3)

49.6 (9.6)

49.8 (10.2)

0.64

0.09

Body fat mass, kg

18.4 (8.9)

20.2 (11.1)

21.5 (10.4)

0.02

19.4 (10.9)

19.5 (10.2)

19.6 (9.4)

0.79

0.05

Trunk fat mass, kg

8.87 (4.38)

9.43 (5.28)

10.28 (4.80)

0.03

9.03 (4.69)

9.12 (4.57)

9.49 (4.54)

0.42

0.19

Legs fat mass, kg

6.61 (3.39)

7.51 (4.16)

8.00 (4.24)

0.02

6.88 (4.18)

7.29 (4.38)

7.12 (3.70)

0.35

0.07

Total ALP U/l

168 (37)

193 (75)

208 (82)

0.04

173 (49)

227 (67)

221 (53)

0.001

0.47

Osteocalcin, μg/l

19.3 (7.6)

37.8 (15.0)

29.7 (12.8)

0.003

15.7 (5.1)

24.5 (8.5)

22.6 (12.6)

0.005

0.19

ß-crosslaps, μg/l

353 (186)

552 (267)

525 (240)

0.03

302 (161)

582 (277)

473 (226)

0.001

0.56

Calcium, mmoles/l

2.28 (0.08)

2.34 (0.10)

2.36 (0.08)

0.02

2.29 (0.11)

2.32 (0.15)

2.32 (0.13)

0.31

0.22

25-OH vitamine D3, μg/l

20.7 (8.2)

22.1 (9.1)

16.4 (7.2)

0.27

19.4 (12.0)

19.5 (12.7)

15.7 (9.6)

0.12

0.81

1,25—diOH-vit D3, ng/l

49.1 (18.7)

42.9 (8.3)

58.9 (16.6)

0.29

49.3 (18.4)

51.6 (17.6)

61.1 (14.7)

0.04

0.54

Parathormone, ng/l

34.1 (12.9)

36.7 (12.7)

53.4 (20.0)

0.01

35.1 (13.3)

47.8 (19.6)

46.5 (12.5)

0.001

0.78