|
+ PI
|
+ NNRTI
|
|---|
|
(n = 16)
|
(n = 19)
|
|---|
|
Parameter*
|
Month 0
|
Month 9
|
Month 21
|
p, trend
|
Month 0
|
Month 9
|
Month 21
|
p, trend
|
p, time X treatment interaction
|
|---|
|
CD4 lymphocytes /ml
|
240 (153)
|
376 (158)
|
497 (189)
|
0.001
|
241 (131)
|
445 (167)
|
493 (127)
|
0.001
|
0.54
|
|
Viral load, log10/ml
|
5.05 (0.85)
|
2.08 (0.85)
|
1.62 (0.07)
|
0.001
|
5.04 (0.55)
|
1.91 (0.88)
|
1.59 (0.01)
|
0.001
|
0.99
|
|
Cholesterol, g/l
|
1.88 (0.45)
|
2.22 (0.66)
|
2.29 (0.41)
|
0.001
|
1.61 (0.34)
|
1.95 (0.46)
|
2.03 (0.41)
|
0.001
|
0.99
|
|
HDL-cholesterol, g/l
|
0.44 (0.08)
|
0.45 (0.10)
|
0.52 (0.15)
|
0.06
|
0.38 (0.10)
|
0.52 (0.16)
|
0.56 (0.16)
|
0.001
|
0.003
|
|
Triglycerides, g/l
|
1.14 (0.58)
|
1.99 (1.68)
|
1.75 (0.82)
|
0.002
|
0.99 (0.48)
|
1.34 (1.64)
|
1.31 (0.97)
|
0.26
|
0.06
|
|
Glucose, g/l
|
0.84 (0.08)
|
0.88 (0.08)
|
0.87 (0.07)
|
0.14
|
0.83 (0.09)
|
0.94 (0.08)
|
0.90 (0.07)
|
0.001
|
0.08
|
|
Lactate, mmoles/l
|
0.93 (0.28)
|
1.06 (0.39)
|
1.11 (0.44)
|
0.24
|
0.98 (0.28)
|
0.94 (0.24)
|
0.93 (0.35)
|
0.68
|
0.19
|
|
Albumin, g/l
|
39.0 (4.9)
|
42.6 (2.0)
|
42.5 (2.0)
|
0.006
|
41.7 (3.7)
|
43.1 (3.5)
|
42.9 (2.5)
|
0.07
|
0.05
|
|
Cockroft (ml/min)
|
83.9
|
82.9
|
86.1
|
0.73
|
102.3
|
103.1
|
104
|
0.66
|
0.97
|
|
Waist circumference, cm
|
83.2 (11.3)
|
87.5 (16.7)
|
89.7 (13.7)
|
0.04
|
82.3 (7.4)
|
82.5 (8.3)
|
81.9 (9.1)
|
0.51
|
0.03
|
|
BMI, kg/m2
|
23.6 (3.6)
|
25.0 (4.9)
|
25.7 (5.5)
|
0.02
|
23.9 (3.6)
|
24.0 (3.7)
|
24.3 (3.7)
|
0.73
|
0.03
|
|
Body Mineral content, kg
|
3.02 (0.69)
|
2.97 (0.63)
|
2.93 (0.58)
|
0.06
|
3.11 (0.56)
|
3.08 (0.57)
|
3.04 (0.53)
|
0.008
|
0.58
|
|
L2-L4 BMD, g/cm2
|
1.234
|
1.182 (0.226)
|
1.186 (0.238)
|
0.001
|
1.249 (0.178)
|
1.232 (0.196)
|
1.230
|
0.04
|
0.05
|
|
(0.234)
|
(0.176)
|
|
Body lean mass, kg
|
46.3 (8.8)
|
48.2 (10.9)
|
48.9 (11.2)
|
0.05
|
49.4 (10.3)
|
49.6 (9.6)
|
49.8 (10.2)
|
0.64
|
0.09
|
|
Body fat mass, kg
|
18.4 (8.9)
|
20.2 (11.1)
|
21.5 (10.4)
|
0.02
|
19.4 (10.9)
|
19.5 (10.2)
|
19.6 (9.4)
|
0.79
|
0.05
|
|
Trunk fat mass, kg
|
8.87 (4.38)
|
9.43 (5.28)
|
10.28 (4.80)
|
0.03
|
9.03 (4.69)
|
9.12 (4.57)
|
9.49 (4.54)
|
0.42
|
0.19
|
|
Legs fat mass, kg
|
6.61 (3.39)
|
7.51 (4.16)
|
8.00 (4.24)
|
0.02
|
6.88 (4.18)
|
7.29 (4.38)
|
7.12 (3.70)
|
0.35
|
0.07
|
|
Total ALP U/l
|
168 (37)
|
193 (75)
|
208 (82)
|
0.04
|
173 (49)
|
227 (67)
|
221 (53)
|
0.001
|
0.47
|
|
Osteocalcin, μg/l
|
19.3 (7.6)
|
37.8 (15.0)
|
29.7 (12.8)
|
0.003
|
15.7 (5.1)
|
24.5 (8.5)
|
22.6 (12.6)
|
0.005
|
0.19
|
|
ß-crosslaps, μg/l
|
353 (186)
|
552 (267)
|
525 (240)
|
0.03
|
302 (161)
|
582 (277)
|
473 (226)
|
0.001
|
0.56
|
|
Calcium, mmoles/l
|
2.28 (0.08)
|
2.34 (0.10)
|
2.36 (0.08)
|
0.02
|
2.29 (0.11)
|
2.32 (0.15)
|
2.32 (0.13)
|
0.31
|
0.22
|
|
25-OH vitamine D3, μg/l
|
20.7 (8.2)
|
22.1 (9.1)
|
16.4 (7.2)
|
0.27
|
19.4 (12.0)
|
19.5 (12.7)
|
15.7 (9.6)
|
0.12
|
0.81
|
|
1,25—diOH-vit D3, ng/l
|
49.1 (18.7)
|
42.9 (8.3)
|
58.9 (16.6)
|
0.29
|
49.3 (18.4)
|
51.6 (17.6)
|
61.1 (14.7)
|
0.04
|
0.54
|
|
Parathormone, ng/l
|
34.1 (12.9)
|
36.7 (12.7)
|
53.4 (20.0)
|
0.01
|
35.1 (13.3)
|
47.8 (19.6)
|
46.5 (12.5)
|
0.001
|
0.78
|
- * mean value (standard deviation).
