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Table 2 Changes in immuno-virological, haematological and metabolic markers, anthropometric and body composition parameters, and in bone markers as a function of treatment time

From: Early loss of bone mineral density is correlated with a gain of fat mass in patients starting a protease inhibitor containing regimen: the prospective Lipotrip study

+ PI + NNRTI
(n = 16) (n = 19)
Parameter* Month 0 Month 9 Month 21 p, trend Month 0 Month 9 Month 21 p, trend p, time X treatment interaction
CD4 lymphocytes /ml 240 (153) 376 (158) 497 (189) 0.001 241 (131) 445 (167) 493 (127) 0.001 0.54
Viral load, log10/ml 5.05 (0.85) 2.08 (0.85) 1.62 (0.07) 0.001 5.04 (0.55) 1.91 (0.88) 1.59 (0.01) 0.001 0.99
Cholesterol, g/l 1.88 (0.45) 2.22 (0.66) 2.29 (0.41) 0.001 1.61 (0.34) 1.95 (0.46) 2.03 (0.41) 0.001 0.99
HDL-cholesterol, g/l 0.44 (0.08) 0.45 (0.10) 0.52 (0.15) 0.06 0.38 (0.10) 0.52 (0.16) 0.56 (0.16) 0.001 0.003
Triglycerides, g/l 1.14 (0.58) 1.99 (1.68) 1.75 (0.82) 0.002 0.99 (0.48) 1.34 (1.64) 1.31 (0.97) 0.26 0.06
Glucose, g/l 0.84 (0.08) 0.88 (0.08) 0.87 (0.07) 0.14 0.83 (0.09) 0.94 (0.08) 0.90 (0.07) 0.001 0.08
Lactate, mmoles/l 0.93 (0.28) 1.06 (0.39) 1.11 (0.44) 0.24 0.98 (0.28) 0.94 (0.24) 0.93 (0.35) 0.68 0.19
Albumin, g/l 39.0 (4.9) 42.6 (2.0) 42.5 (2.0) 0.006 41.7 (3.7) 43.1 (3.5) 42.9 (2.5) 0.07 0.05
Cockroft (ml/min) 83.9 82.9 86.1 0.73 102.3 103.1 104 0.66 0.97
Waist circumference, cm 83.2 (11.3) 87.5 (16.7) 89.7 (13.7) 0.04 82.3 (7.4) 82.5 (8.3) 81.9 (9.1) 0.51 0.03
BMI, kg/m2 23.6 (3.6) 25.0 (4.9) 25.7 (5.5) 0.02 23.9 (3.6) 24.0 (3.7) 24.3 (3.7) 0.73 0.03
Body Mineral content, kg 3.02 (0.69) 2.97 (0.63) 2.93 (0.58) 0.06 3.11 (0.56) 3.08 (0.57) 3.04 (0.53) 0.008 0.58
L2-L4 BMD, g/cm2 1.234 1.182 (0.226) 1.186 (0.238) 0.001 1.249 (0.178) 1.232 (0.196) 1.230 0.04 0.05
(0.234) (0.176)
Body lean mass, kg 46.3 (8.8) 48.2 (10.9) 48.9 (11.2) 0.05 49.4 (10.3) 49.6 (9.6) 49.8 (10.2) 0.64 0.09
Body fat mass, kg 18.4 (8.9) 20.2 (11.1) 21.5 (10.4) 0.02 19.4 (10.9) 19.5 (10.2) 19.6 (9.4) 0.79 0.05
Trunk fat mass, kg 8.87 (4.38) 9.43 (5.28) 10.28 (4.80) 0.03 9.03 (4.69) 9.12 (4.57) 9.49 (4.54) 0.42 0.19
Legs fat mass, kg 6.61 (3.39) 7.51 (4.16) 8.00 (4.24) 0.02 6.88 (4.18) 7.29 (4.38) 7.12 (3.70) 0.35 0.07
Total ALP U/l 168 (37) 193 (75) 208 (82) 0.04 173 (49) 227 (67) 221 (53) 0.001 0.47
Osteocalcin, μg/l 19.3 (7.6) 37.8 (15.0) 29.7 (12.8) 0.003 15.7 (5.1) 24.5 (8.5) 22.6 (12.6) 0.005 0.19
ß-crosslaps, μg/l 353 (186) 552 (267) 525 (240) 0.03 302 (161) 582 (277) 473 (226) 0.001 0.56
Calcium, mmoles/l 2.28 (0.08) 2.34 (0.10) 2.36 (0.08) 0.02 2.29 (0.11) 2.32 (0.15) 2.32 (0.13) 0.31 0.22
25-OH vitamine D3, μg/l 20.7 (8.2) 22.1 (9.1) 16.4 (7.2) 0.27 19.4 (12.0) 19.5 (12.7) 15.7 (9.6) 0.12 0.81
1,25—diOH-vit D3, ng/l 49.1 (18.7) 42.9 (8.3) 58.9 (16.6) 0.29 49.3 (18.4) 51.6 (17.6) 61.1 (14.7) 0.04 0.54
Parathormone, ng/l 34.1 (12.9) 36.7 (12.7) 53.4 (20.0) 0.01 35.1 (13.3) 47.8 (19.6) 46.5 (12.5) 0.001 0.78
  1. * mean value (standard deviation).