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Table 3 Mutation patterns of eight isolates of M. tuberculosis

From: Resistance of Mycobacterium tuberculosis to antibiotics in Lao PDR: first multicentric study conducted in 3 hospitals

Patient number (hospital) Previously treated case Mutations conferring resistance to
INH RMP FLQ AG/CP EMB
425 (LP) No katG S315T - - - -
inhA C15T
472 (TK) No inhA C15T - - - -
977 (MV) No katG S315T - - - -
454 (MV) Yes katG S315T - - - -
446 (LP) No inhA C15T - - rrs C1402T -
480 (TK) No katG S315T - - rrs C1402T -
165 (LP) Yes katG deleted - - rrs C1402T -
175 (TK) Yes katG S315T rpoB H526Y gyrA A90V rrs C1402T embB M306V
Total 8 1 1 4 1
  1. LP Luang Prabang, MV Mahosot Vientiane, TK Thakhek, INH isionazid, RMP rifampycin, FLQ fluoroquinolones, AG/CP aminoglycosides, cyclic peptides, EMB ethambutol.
  2. (−) Presence of all wild type probes and none mutation probe observed.