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Table 1 Comparison between adults and children with viridans streptococcal bacteremia during febrile neutropenia

From: Clinical characteristics and antimicrobial susceptibilities of viridans streptococcal bacteremia during febrile neutropenia in patients with hematologic malignancies: a comparison between adults and children

Factor Adults (≥ 20 years old) (n=141) Children (< 20 years old) (n=61) p-value
Age (years) 44 (36-54) 9 (3-15)  
Gender (male) 67 (47.5) 41 (67.2) 0.010
Underlying disease    0.215
 Acute myeloid leukemia 103 (73.1) 44 (72.1)  
 Acute lymphoblastic leukemia 23 (16.3) 13 (21.3)  
 Other leukemias 4 (2.8) 3 (4.9)  
 Non-Hodgkin lymphoma 8 (5.7) 1 (1.6)  
 Multiple myeloma 3 (2.1) 0 (0.0)  
Complete remission status 84 (59.6) 40 (65.6) 0.421
Preceding therapy    0.103
 Conventional chemotherapy 131 (92.9) 61 (100.0)  
 Hematopoietic cell transplantation    
   Autologous 8 (5.7) 0 (0.0)  
   Allogeneic 2 (1.4) 0 (0.0)  
Duration after the preceding therapy (days) 12 (10-13) 13 (12-14) <0.001
Antibacterial prophylaxis*    < 0.001
 None 4 (2.9) 1 (1.6)  
 Trimethoprim/sulfamethoxazole 0 (0) 53 (86.9)  
 Ciprofloxacin 134 (97.1) 7 (11.5)  
Accompanying symptoms    
 Oral mucositis 36 (25.5) 5 (8.2) 0.005
 Cough 9 (6.4) 12 (19.7) 0.004
 Sputum 5 (3.5) 4 (6.6) 0.458
 Rhinorrhea 1 (0.7) 0 (0.0) 1.000
 Diarrhea 46 (32.6) 14 (23.0) 0.167
 Abdominal pain 35 (24.8) 3 (4.9) 0.001
Polymicrobial infection    
 Other bacterial infection 18 (12.8) 4 (6.6) 0.193
 Fungal infection 16 (11.3) 2 (3.3) 0.065
Complications attributable to VSB 22 (15.6) 4 (6.6) 0.078
 Ventilator care 5 (3.5) 3 (4.9) 0.700
 Acute respiratory distress syndrome 4 (2.8) 2 (3.3) 1.000
 Shock 22 (15.6) 4 (76.6) 0.078
 Death 3 (2.1) 1 (1.6) 1.000
Overall death 12 (8.5) 2 (3.3) 0.236
Laboratory findings    
  White blood cell count (/μL) 50 (20-160) 60 (30-135) 0.127
  Absolute neutrophil count (/μL) 0 (0-0) 0 (0-0) 0.228
  Duration of neutropenia before the diagnosis of VSB (days) 6 (4-7) 6 (4-8) 0.138
  Total duration of neutropenia (days) 17 (12-24) 15 (11-22) 0.823
 Peak C-reactive protein level (mg/dL) 19.6 (13.2-26.5) 18.6 (9.7-25.5) 0.157
  1. Data are median (inter quartile range) or No. (%) of cases.
  2. VSB viridans streptococcal bacteremia.
  3. *Antibacterial prophylaxis was evaluated in 199 patients (138 adults, 61 children) except 3 adults who had been undergoing ceftazidime treatment.