Demonstration of the biomechanical results. A cure time [min], B compressive strength [MPa], C bending strength [MPa], D bending modulus [MPa]. The investigation of the biochemical characteristics shows a significant change after adding 1.225% of tigecyclin per weight to PMMA-bone cement compared to customary products with gentamicin. A shows the average cure time [min] of the 2 investigation groups. The average compressive strength [MPa] of the 2 different groups is shown in B. C shows the bending strength [MPa] and D the bending modulus [MPa] of the 2 investigation groups. The results are shown as means ± SD of three independent experiments in case of the cure time and six independent experiments for the compressive strength, bending strength and bending modulus. * p ≤ 0.05.