TY - JOUR AU - Kreis, Carolin A. AU - Raschke, Michael J. AU - Roßlenbroich, Steffen B. AU - Tholema-Hans, Nancy AU - Löffler, Bettina AU - Fuchs, Thomas PY - 2013 DA - 2013/06/05 TI - Therapy of intracellular Staphylococcus aureus by tigecyclin JO - BMC Infectious Diseases SP - 267 VL - 13 IS - 1 AB - In the fields of traumatology and orthopaedics staphylococci are the most frequently isolated pathogens. Staphylococcus aureus and Staphylococcus epidermidis are known to be the major causative agents of osteomyelitis. The increasing number of multiresistant Staphylococcus aureus and resistant coagulase-negative staphylococci as a trigger of complicated osteomyelitis and implant-associated infections is a major problem. Antibiotic therapy fails in 20% of cases. Therefore the development of novel antibiotics becomes necessary. SN - 1471-2334 UR - https://doi.org/10.1186/1471-2334-13-267 DO - 10.1186/1471-2334-13-267 ID - Kreis2013 ER -