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Table 3 Correlates of change in Log 10 -transformed angiopoietin-2 level after ART initiation, GEE analysis

From: A prospective study of endothelial activation biomarkers, including plasma angiopoietin-1 and angiopoietin-2, in Kenyan women initiating antiretroviral therapy

 

Bivariable model a

Multivariable model 1 b

Multivariable model 2 c

 

Mean change (95% CI)

P value

Mean change (95% CI)

P value

Mean change (95%)

P value

Baseline predictor

      

Hormonal status

      

  No exogenous hormones

Reference

 

Reference

 

Reference

 

  Oral contraceptive pills

0.474 (0.175 to 0.772)

0.002

0.661 (0.393 to 0.929)

<0.001

0.660 (0.397 to 0.922)

<0.001

  DMPA

0.166 (−0.080 to 0.411)

0.19

0.078 (−0.152 to 0.307)

0.51

0.082 (−0.144 to 0.308)

0.48

  Norplant

−0.290 (−0.960 to 0.380)

0.40

−0.389 (−1.012 to 0.235)

0.22

−0.396 (−0.997 to 0.205)

0.20

Nutritional status

      

  Adequate nutrition

Reference

     

  Mild to moderate malnutrition

−0.278 (−0.670 to 0.113)

0.16

    

  Severe malnutrition

−0.625 (−0.761 to −0.489)

<0.001

    

WHO stage

      

  Stage I

Reference

 

Reference

 

Reference

 

  Stage II

0.031 (−0.344 to 0.407)

0.87

−0.088 (−0.439 to 0.263)

0.62

−0.061 (−0.413 to 0.291)

0.73

  Stage III

−0.151 (−0.466 to 0.163)

0.35

−0.307 (−0.621 to 0.006)

0.06

−0.291 (−0.604 to 0.022)

0.07

  Stage IV

−0.546 (−0.998 to −0.093)

.02

−0.492 (−0.946 to −0.039)

.03

−0.444 (−0.892 to 0.004)

0.05

CD4 Category (cells/μL)

      

  <200

Reference

     

  200–350

−0.260 (−0.515 to −0.006)

0.04

    

  >350

0.060 (−0.081 to 0.202)

0.40

    

Time-dependent predictor

      

Log10 Angiopoietin-1 (ng/mL)

0.683 (0.144 to 1.222)

0.01

    

Change in Log10 ANG-1 (ng/mL)

0.709 (0.134 to 1.284)

0.02

0.953 (0.536 to 1.370)

<0.001

0.944 (0.534 to 1.354)

<0.001

Suppressed Plasma HIV-1 RNA

−0.158 (−0.381 to 0.064)

0.16

−0.182 (−0.378 to 0.014)

0.07

  

Log10 Plasma HIV-1 RNA (copies/mL)

0.142 (0.050 to 0.235)

0.003

  

0.128 (0.029 to 0.228)

0.012

Change in Log10 Plasma HIV-1 RNA (copies/mL)

0.102 (0.022 to 0.182)

0.01

    

Hormonal status

      

  No exogenous hormones

Reference

 

Reference

 

Reference

 

  Oral contraceptive pills

0.367 (0.130 to 0.604)

0.002

0.019 (−0.160 to 0.199)

0.83

0.042 (−0.127 to 0.210)

0.63

  DMPA

0.264 (0.021 to 0.506)

0.03

0.098 (−0.130 to 0.326)

0.40

0.123 (−0.108 to 0.353)

0.30

  Norplant

−0.353 (−1.090 to 0.383)

0.35

—

 

—

 

  Pregnant

1.152 (0.591 to 1.712)

<0.001

1.302 (0.795 to 1.810)

<0.001

1.299 (0.749 to 1.849)

<0.001

Nutritional status

      

  Adequate nutrition

Reference

 

Reference

 

Reference

 

  Mild to moderate malnutrition

−0.185 (−0.583 to 0.213)

0.36

−0.325 (−0.615 to −0.035)

0.03

−0.353 (−0.664 to −0.042)

0.03

  Severe malnutrition

0.627 (0.441 to 0.813)

<0.001

0.688 (0.406 to 0.970)

<0.001

0.729 (0.433 to 1.015)

<0.001

  Current tuberculosis

0.635 (0.191 to 1.079)

0.005

0.557 (0.137 to 0.977)

0.009

0.491 (0.053 to 0.929)

0.03

CD4 Category (cells/μL)

      

  <200

Reference

     

  200–350

−0.266 (−0.526 to −0.007)

0.04

    

  >350

−0.145 (−0.435 to 0.145)

0.33

    
  1. CI Confidence interval, GEE generalized estimating equations.
  2. a Adjusted for baseline log10 angiopoietin-2 level (ng/mL).
  3. b Adjusted for baseline log10 angiopoietin-2 level (ng/mL) and other covariates presented. Change in ANG-1 and virologic suppression were included a priori in multivariable modeling.
  4. c Adjusted for baseline log10 angiopoietin-2 level (ng/mL) and other covariates presented. Change in ANG-1 was included a priori and log10 plasma HIV-1 RNA was substituted for virologic suppression in multivariable modeling.
  5. N.B. Variables not significant at p < 0.10 in bivariate analysis are not included in the table, including baseline ANG-1, baseline plasma HIV-1 RNA, baseline age, baseline Karnofsky Performance Score, baseline tuberculosis, tobacco use, alcohol use, and time-dependent Karnofsky Performance Score. Data from one visit with an outlier value for log10 angiopoietin-1 have been excluded, as described in the text.
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BMC Infectious Diseases

ISSN: 1471-2334

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