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Table 2 Correlates of change in log 10 angiopoietin-1 level after ART initiation, GEE analysis

From: A prospective study of endothelial activation biomarkers, including plasma angiopoietin-1 and angiopoietin-2, in Kenyan women initiating antiretroviral therapy

 

Bivariable model a

Multivariable model b

 

Mean change, ( 95% CI)

P value

Mean change, ( 95% CI)

P value

Baseline predictor

    

Hormonal status

    

  No exogenous hormones

Reference

 

Reference

 

  Oral contraceptive pills

−0.049 (−0.172 to 0.073)

0.43

−0.154 (−0.330 to 0.022)

0.09

  DMPA

0.059 (−0.003 to 0.121)

0.06

0.028 (−0.055 to 0.110)

0.51

  Norplant

0.013 (−0.061 to 0.086)

0.74

0.039 (−0.052 to 0.131)

0.40

Nutritional status

    

  Adequate nutrition

Reference

 

Reference

 

  Mild to moderate malnutrition

−0.089 (−0.198 to 0.020)

0.11

−0.083 (−0.192 to 0.026)

0.14

  Severe malnutrition

−0.191 (−0.236 to −0.147)

<0.001

−0.212 (−0.286 to −0.137)

<0.001

Karnofsky Performance Score

    

  Asymptomatic or mild symptoms (90–100)

Reference

 

Reference

 

  Moderate symptoms (80)

0.031 (−0.046 to 0.109)

0.43

0.039 (−0.041 to 0.119)

0.34

  Unable to work (<80)

0.100 (0.030 to 0.170)

0.005

0.091 (0.015 to 0.166)

0.02

WHO Stage

    

  Stage I

Reference

   

  Stage II

−0.016 (−0.103 to 0.071)

0.72

  

  Stage III

−0.070 (−0.138 to −0.002)

0.04

  

  Stage IV

−0.092 (−0.194 to 0.009)

0.08

  

CD4 Category (cells/μL)

    

  <200

Reference

   

  200–350

0 (−0.088 to 0.087)

0.98

  

  >350

−0.038 (−0.070 to −0.007)

0.02

  

Time-dependent predictor

    

Change in Log10 Angiopoietin-2 (ng/mL)

0.037 (−0.016 to 0.091)

0.17

0.053 (0.018 to 0.087)

0.003

Suppressed Plasma HIV-1 RNA

0.042 (−0.015 to 0.098)

0.15

0.055 (0 to 0.109)

0.05

Hormonal status

    

  No exogenous hormones

Reference

 

Reference

 

  Oral contraceptive pills

−0.013 (−0.200 to 0.173)

0.89

0.044 (−0.183 to 0.271)

0.70

  DMPA

0.053 (−0.011 to 0.117)

0.10

0.020 (−0.065 to 0.105)

0.65

  Norplant

0.024 (−0.068 to 0.115)

0.61

—

 

  Pregnant

−0.200 (−0.371 to −0.029)

0.02

−0.275 (−0.469 to −0.082)

0.005

Nutritional status

    

  Adequate nutrition

Reference

   

  Mild to moderate malnutrition

0.044 (−0.151 to 0.238)

0.63

  

  Severe malnutrition

−0.093 (−0.124 to −0.062)

<0.001

  
  1. CI Confidence interval, GEE generalized estimating equations.
  2. a Adjusted for baseline log10 angiopoietin-1 level (ng/mL).
  3. b Adjusted for baseline log10 angiopoietin-1 level (ng/mL) and other covariates presented. Change in ANG-2 and virologic suppression were included a priori in multivariable modeling.
  4. N.B. Variables not significant at p < 0.10 in bivariate analysis are not included in the table, including baseline ANG-2, baseline plasma HIV-1 RNA, baseline age, baseline tuberculosis, tobacco use, alcohol use, time-dependent ANG-2, time-dependent plasma HIV-1 RNA, change in plasma HIV-1 RNA, time-dependent Karnofsky Performance Score, time-dependent tuberculosis, and time-dependent CD4 category. Data from one visit with an outlier value for log10 angiopoietin-1 have been excluded, as described in the text.
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BMC Infectious Diseases

ISSN: 1471-2334

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