|
Genotype
|
Neuropsychiatric disorders
|
p value
|
|---|
| |
No
| |
Yes
|
|---|
|
n
|
%
|
n
|
%
|
|---|
|
CYP2B6*6
|
*1/*1
|
21
|
42
|
61
|
44.5
|
0.16
|
|
*1/*6
|
28
|
56
|
63
|
46
| |
|
*6/*6
|
1
|
2
|
13
|
9.5
| |
|
CYP2B6*11
|
*1/*1
|
41
|
82
|
111
|
78.2
|
0.17
|
|
*1/*11
|
8
|
16
|
31
|
21.8
| |
|
*11/*11
|
1
|
2
|
0
|
0
| |
|
CYP2A6*9
|
*1/*1
|
39
|
84.8
|
98
|
79.7
|
0.51
|
|
*1/*9
|
7
|
15.2
|
22
|
17.9
| |
|
*9/*9
|
0
|
0
|
3
|
2.4
| |
|
CYP2A6*17
|
*1/*1
|
38
|
90.5
|
104
|
83.9
|
0.3
|
|
*1/*17
|
3
|
7.1
|
19
|
15.3
| |
|
*17/*17
|
1
|
2.4
|
1
|
0.8
| |
|
No. of CYP3A5*1 allelesa
|
zero
|
15
|
30
|
31
|
21.8
|
0.48
|
|
One
|
24
|
48
|
79
|
55.6
| |
|
Two
|
11
|
22
|
32
|
22.5
| |
|
ABCB1 (rs3842
|
*0/*0
|
29
|
63
|
87
|
65.4
|
0.95
|
|
*0/*1
|
16
|
34.8
|
43
|
32.3
| |
|
*1/*1
|
1
|
2.2
|
3
|
2.3
| |
|
ABCB1 c.3435C/T
|
CC
|
37
|
74
|
109
|
77.9
|
0.68
|
|
CT
|
13
|
26
|
30
|
21.4
| |
|
TT
|
0
|
0
|
1
|
0.7
| |
|
NR1I3 rs3003569CT
|
TT
|
10
|
21.7
|
29
|
23
|
0.06
|
|
TC
|
16
|
34.8
|
65
|
51.6
| |
|
CC
|
20
|
43.5
|
32
|
25.4
| |
|
Alleles
|
Frequency
(%)
|
Frequency
(%)
| |
|
CYP2B6*6
|
30
|
32.5
|
0.21
|
|
CYP2B6*11
|
10
|
10.9
|
0.78
|
|
CYP2A6*9
|
7.61
|
11.38
|
0.31
|
|
CYP2A6*17
|
5.95
|
8.46
|
0.55
|
|
No. of CYP3A5*1 allele
|
46
|
50.4
|
0.56
|
|
ABCB1 rs3842
|
19.6
|
18.4
|
0.80
|
|
ABCB1 c.3435T
|
13
|
11.4
|
0.67
|
|
NR1I3 rs3003569 T
|
39.1
|
48.8
|
0.11
|
- P value from binary logistic regression is presented.
-
a Haplotype analyses indicate no linkage between CYP3A5 SNPs thus subjects were grouped based on number of functional CYP3A5 allele (CYP3A5*1) for statistical analysis.
