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Table 3 Serological assay interpretation per the Mikrogen assay

From: Reliability of the Siemens Enzygnost and Novagnost Epstein–Barr Virus assays for routine laboratory diagnosis: agreement with clinical diagnosis and comparison with the Merifluor Epstein–Barr Virus immunofluorescence assay

IgG strip IgM strip IgA Patient status
EBNA-1 p18 p23 BZLF1 EAs (p54, p138) p54 p138 ZEBRA p23   
EBV negative
+ or – + or – + or – + + or – + or – + or –   Primary infection
+ or – + or – + or – + or – + + or – + or –  
+ + weak + or -   Past infection
+ + weak + weak + weak + weak + weak +   Secondary reactivationa
+b + + + + – or weak + – or weak + – or weak + – or weak + EA + BZLF1+ VCA+ Reactivation
+ + weak + weak + weak + weak + weak + High Nasopharyngeal cancer
EBV-associated lymphoma
IgG/IgM/IgA: one isolated band (with the exception of the markers IgG EBNA-1 and IgG VCA) in only one antibody class and if all other antibody classes are negative No definitive test result (retest after 2–3 weeks)
  1. a No clinical relevance.
  2. b In a very few cases, loss of anti–EBNA-1 antibodies.