Skip to main content

Table 5 Linear regression models for square-root transformed C min and C max

From: Factors affecting antiretroviral pharmacokinetics in HIV-infected women with virologic suppression on combination antiretroviral therapy: a cross-sectional study

  Cmin Cmax
Variables Beta 95% CI p-value Beta 95% CI p-value
Age (per 10 years) 0.02 (−0.07 - 0.11) 0.62 0.00 (−0.04 - 0.05) 0.95
Race       
   White Reference      
   Black −0.16 (−0.35 - 0.03) 0.09 −0.06 (−0.16 - 0.04) 0.25
   Other −0.20 (−0.50 - 0.11) 0.20 0.01 (−0.15 - 0.17) 0.91
Risk Factor       
   IDU −0.21 (−0.45 - 0.04) 0.10 −0.10 (−0.23 - 0.02) 0.10
   Endemic country −0.08 (−0.26 - 0.10) 0.38 −0.07 (−0.16 - 0.02) 0.14
   Heterosexual contact 0.13 (−0.05 - 0.32) 0.16 0.07 (−0.03 - 0.16) 0.16
   Blood transfusion −0.08 (−0.38 - 0.22) 0.60 −0.08 (−0.23 - 0.07) 0.31
   Unknown −0.06 (−0.34 - 0.23) 0.69 0.01 (−0.14 - 0.15) 0.90
Years since HIV diagnosis (per 10 years) 0.00 (−0.00 - 0.00) 0.84 −0.00 (−0.00 - 0.00) 0.53
Baseline CD4 (per 100/μL) 0.02 (−0.02 - 0.06) 0.28 0.00 (−0.02 - 0.02) 0.97
Baseline CD4 > 200/μL 0.07 (−0.11 - 0.24) 0.46 0.03 (−0.06 - 0.12) 0.51
Current CD4 (per 100/μL) 0.04 ( 0.00 - 0.08) 0.03 0.01 (−0.01 - 0.03) 0.61
Current CD4 > 200/μL 0.30 (−0.25 - 0.84) 0.28 0.16 (−0.12 - 0.44) 0.26
Baseline VL (log10 copies/mL) −0.02 (−0.09 - 0.06) 0.64 −0.00 (−0.04 - 0.03) 0.81
AIDS diagnosis 0.07 (−0.12 - 0.27) 0.46 0.06 (−0.04 - 0.16) 0.27
Years on current regimen −0.01 (−0.05 - 0.03) 0.68 −0.00 (−0.02 - 0.02) 0.83
Hepatitis B co-infection 0.22 (−0.34 - 0.78) 0.44 −0.04 (−0.33 - 0.24) 0.76
Hepatitis C co-infection 0.18 (−0.07 - 0.44) 0.17 −0.10 (−0.23 - 0.03) 0.14
Smoking Status       
   Smoker Reference      
   Previous Smoker 0.02 (−0.27 - 0.31) 0.89 0.05 (−0.10 - 0.20) 0.49
Never −0.13 (−0.31 - 0.06) 0.18 0.02 (−0.08 - 0.11) 0.70
Hypertension 0.14 (−0.12 - 0.41) 0.28 0.02 (−0.12 - 0.15) 0.82
Diabetes 0.02 (−0.43 - 0.47) 0.94 −0.05 (−0.28 - 0.18) 0.66
Weight (per kg) 0.00 (−0.00 - 0.01) 0.36 0.00 (−0.00 - 0.00) 0.32
BMI (per kg/m2) 0.00 (−0.01 - 0.02) 0.47 0.00 (−0.00 - 0.01) 0.64
Menopausal (self-reported) 0.05 (−0.14 - 0.25) 0.59 0.03 (−0.07 - 0.14) 0.55
  1. IDU, injection drug use; VL, viral load; AIDS, acquired immunodeficiency syndrome; BMI, body mass index.