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Table 2 Reference population mean and Study Participants C min and C max by antiretroviral drug

From: Factors affecting antiretroviral pharmacokinetics in HIV-infected women with virologic suppression on combination antiretroviral therapy: a cross-sectional study

      C min C max
Antiretroviral agent* Reference Dose (mg) Freq N Population mean (ug/mL) Study participants median (IQR) Population mean (ug/mL) Study participants median (IQR)
Atazanavir** [33] 400 QD 9 273 214 (95–373) 3152 1870 (979–2950)
Atazanavir** boosted with ritonavir [33] 300 QD 18 862 835 (663–1220) 5233 3430 (2670–4450)
Lopinavir boosted with ritonavir [34] 400 BID 16 5500 6660 (4360–7710) 9800 8420 (7240–11600)
Lopinavir boosted with ritonavir [34] 800 QD 4 1700 6445 (2452–8260) 11800 11685 (7403–14900)
Efavirenz [35] 600 QD 16 1768 1680 (1180–3450) 4072 3235 (2330–5180)
Nevirapine [36] 200 BID 11 3730 5270 (3380–7190) 5740 5510 (4810–7860)
Nevirapine [36] 400 QD 8 2880 5995 (2590–7275) 6690 6400 (4838–9380)
  1. QD, once daily; BID, twice daily; IQR, interquartile range.
  2. *Nucleos(t)ide backbone: of 9 participants on Atazanavir 400 mg QD, all 9 were taking Abacavir/3TC; of 18 participants on Atazanavir/ritonavir 300 mg/100 mg QD, 11 were taking Abacavir/3TC, 3 Tenofivir/FTC, 3 Tenofivir/3TC and 1 Zidovudine/3TC; of 16 participants on Lopinavir/ritonavir 400 mg/100 mg BID, 7 were taking Zidovudine/3TC, 6 Abacavir/3TC, 1 Tenofivir/FTC, 1 Tenofivir/3TC and 1 was on PI monotherapy; of 4 participants on Lopinavir/ritonavir 800 mg/200 mg QD, 2 were taking Tenofivir/FTC, 1 Abacavir/3TC, 1 Didanosine/3TC; of 16 participants on Efavirenz 600 mg QD, 5 were taking Tenofivir/FTC, 5 Abacavir/3TC, 5 Zidovudine/3TC, 1 Tenofovir/3TC; of 11 participants on Nevirapine 200 mg BID, 7 were taking Zidovudine/3TC, 4 Abacavir/3TC; of 8 participants on Nevirapine 400 mg/ QD, 4 were taking Abacavir/3TC, 1 Tenofivir/FTC, 1 Zidovudine/3TC, 1 Tenofivir/3TC, 1 Didanosine/3TC.
  3. ** Of the 27 particpants taking Atazanavir or Atazanvir/ritonavir, none were taking any gastric acid suppression medication.