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Table 3 Predicted miRNA-mRNA interacting pairs by GroupMiR in comparison with miRNA profiling studies

From: MicroRNA regulation and its effects on cellular transcriptome in Human Immunodeficiency Virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts

mRNA-miRNA pairs by GroupMiR Control vs LVL (miRNA) Control vs HVL (miRNA) LVL vs HVL (miRNA)
mRNA miRNA P value Fold Change P value Fold change P value Fold change P value
AIF1 (-2.67) miR-483-5p 0.8026 5.969 0.00410** 17.088 0.000000205** 2.863 0.0125*
AIF1 (-2.67) miR-605 0.9418 1.164 0.871 29.059 0.0000000127** 24.961 0.0000000542**
ALDH1A1 (-2.11) miR-222 0.2438 1.710 0.229 2.558 0.0611 2.856 0.000129**
ALDH1A1 (-2.11) miR-155 0.7276 5.183 0.0570 16.778 0.000103** 3.237 0.000000808**
NCR3 (-2.3) miR-34a 0.1528 1.936 0.547 20.678 0.0000153** 10.681 0.000576**
NCR3 (-2.3) miR-660 0.119 2.276 0.393 6.452 0.00778** 2.835 0.0233*
NRGN (-4.06) miR-210 0.9606 2.931 0.162 10.536 0.000121** 3.591 0.00276**
NRGN (-4.06) miR-564 0.9702 2.467 0.229 11.667 0.00000170** 4.730 0.00307**
IL6 (4.01) miR-144 0.8496 −1.181 0.855 −25.7093 0.00000508** −21.786 0.000241**
IL6 (4.01) miR-376a 0.8812 −1.264 0.697 −2.638 0.0185* −2.088 0.000000797**
IL6 (4.01) miR-935 0.227 −1.706 0.378 −22.431 0.0000000179** −13.141 0.0000135**
CCL2 (4.53) miR-144 0.1506 −1.181 0.855 −25.709 0.00000508** −21.786 0.000241**
CCL2 (4.53) miR-196b 0.1026 2.167 0.121 −1.071 0.898 −2.321 0.00479**
CCL2 (4.53) miR-376a 0.1272 −1.264 0.697 −2.638 0.0185* −2.088 0.000000797**
CCL2 (4.53) miR-503 0.1154 1.624 0.403 −3.256 0.0480* −5.288 0.00788**
CCL2 (4.53) miR-590-3P 0.1122 3.077 0.099 −2.00 0.252 −6.150 0.00000113**
CCL2 (4.53) miR-935 0.1732 −1.706 0.378 −22.431 0.0000000179** −13.141 0.0000135**
CCL8 (5.11) miR-25 0.5172 −1.095 0.878 2.893 0.00117** 3.169 0.00781**
CCL8 (5.11) miR-376a 0.119 −1.264 0.697 −2.638 0.0185* −2.088 0.000000797**
CCL8 (5.11) miR-512-3p 0.1184 −1.508 0.609 3.942 0.0298* 5.950 0.00829**
CCL8 (5.11) miR-518d-3p 0.1302 −1.124 0.892 4.867 0.00491** 5.471 0.00367**
CCL8 (5.11) miR-935 0.4236 −1.706 0.378 −22.431 0.0000000179** −13.141 0.0000135**
  1. Fold changes and p-values for the miRNA and mRNA in infected PBMC compared to the uninfected controls determined by RealTime StatMiner. * = p < 0.05.
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BMC Infectious Diseases

ISSN: 1471-2334

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