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Table 1 Correlation of the detected mutations in the gyrA and gyrB genes with phenotypic DST

From: Detection of second-line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays

Mutation No. of isolates Resistance (mg/L) MIC Bactec MGIT 960 (mg/L)
gyrA gyrB OFX LVX MFX
D94G wt 1 10 8 2
D94Ga wt 12 2 to 10 4 to 16 2
D94Aa wt 6 2 2 0.5 to 2
D94Na wt 1 2 8 4
D94Ha wt 1 10 4 2
D94Ya wt 1 2 4 1
A90Va wt 9 2 to 10 2 to 8 0.5 to 2
S91Pa wt 1 2 2 1
G88C wt 1 10 8 4
A90V + D94Ga wt 1 10 >32 8
A90V + D94Ya wt 1 2 2 1
H70R + G88Aa wt 2 2 2 1 to 2
H70R + A90Va wt 1 2 8 2
S95T D500H 1 2 4 0.5
S95T R485H 1 2 1 0.25
S95T N538D 1 2 2 0.5
S95T wt 1 2 1 0.125
S95T wt 17 S ≤0.5 ≤0.25
wt wt 6 S ≤1 ≤0.25
wt wt (H37Rv) S 0.5 0.125
  1. aadditional mutation S95T.
  2. Resistance to OFX was detected by the absolute concentration method. For LVX and MFX, resistance was defined as LVX (>2 mg/L) and MFX (>0.25 mg/L). The MICs considered to reflect resistance are highlighted in bold.