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Table 1 Correlation of the detected mutations in the gyrA and gyrB genes with phenotypic DST

From: Detection of second-line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays

Mutation

No. of isolates

Resistance (mg/L)

MIC Bactec MGIT 960 (mg/L)

gyrA

gyrB

OFX

LVX

MFX

D94G

wt

1

10

8

2

D94Ga

wt

12

2 to 10

4 to 16

2

D94Aa

wt

6

2

2

0.5 to 2

D94Na

wt

1

2

8

4

D94Ha

wt

1

10

4

2

D94Ya

wt

1

2

4

1

A90Va

wt

9

2 to 10

2 to 8

0.5 to 2

S91Pa

wt

1

2

2

1

G88C

wt

1

10

8

4

A90V + D94Ga

wt

1

10

>32

8

A90V + D94Ya

wt

1

2

2

1

H70R + G88Aa

wt

2

2

2

1 to 2

H70R + A90Va

wt

1

2

8

2

S95T

D500H

1

2

4

0.5

S95T

R485H

1

2

1

0.25

S95T

N538D

1

2

2

0.5

S95T

wt

1

2

1

0.125

S95T

wt

17

S

≤0.5

≤0.25

wt

wt

6

S

≤1

≤0.25

wt

wt

(H37Rv)

S

0.5

0.125

  1. aadditional mutation S95T.
  2. Resistance to OFX was detected by the absolute concentration method. For LVX and MFX, resistance was defined as LVX (>2 mg/L) and MFX (>0.25 mg/L). The MICs considered to reflect resistance are highlighted in bold.