Treatment groupa | ||||
---|---|---|---|---|
Symptom % (95% CI) b | QIV | LD QIV-AS | LD TIV-AS | TIV |
Nc | 105 | 104 | 105 | 105 |
Any symptom | 79.0 (70.0–86.4) | 86.5 (78.4–92.4) | 77.1 (67.9–84.8) | 67.6 (57.8–76.4) |
Grade 3d | 3.8 (1.0–9.5) | 4.8 (1.6–10.9) | 9.5 (4.7–16.8) | 1.9 (0.2–6.7) |
Local Symptoms | 72.4 (62.8–80.7) | 76.9 (67.6–84.6) | 70.5 (60.8–79.0) | 49.5 (39.6–59.5) |
Grade 3 | 0 (0–3.5) | 1.9 (0.2–6.8) | 2.9 (0.6–8.1) | 0 (0–3.5) |
Pain | 72.4 (62.8–80.7) | 76.0 (66.6–83.8) | 70.5 (60.8–79.0) | 49.5 (39.6–59.5) |
Grade 3 | 0 (0–3.5) | 1.9 (0.2–6.8) | 2.9 (0.6–8.1) | 0 (0–3.5) |
Redness | 2.9 (0.6–8.1) | 5.8 (2.1–12.1) | 4.8 (1.6–10.8) | 1.0 (0–5.2) |
>100 mm | 0 (0–3.5) | 0 (0–3.5) | 0 (0–3.5) | 0 (0–3.5) |
Swelling | 2.9 (0.6–8.1) | 3.8 (1.1–9.6) | 6.7 (2.7–13.3) | 1.9 (0.2–6.7) |
>100 mm | 0 (0–3.5) | 0 (0–3.5) | 0 (0–3.5) | 0 (0–3.5) |
General Symptoms | 44.8 (35.0–54.8) | 57.7 (47.6–67.3) | 53.3 (43.3–63.1) | 43.8 (34.1–53.8) |
Grade 3 | 3.8 (1.0–9.5) | 4.8 (1.6–10.9) | 7.6 (3.3–14.5) | 1.9 (0.2–6.7) |
Arthalgia | 5.7 (2.1–12.0) | 24.0 (16.2–33.4) | 12.4 (6.8–20.2) | 10.5 (5.3–18.0) |
Grade 3 | 1.0 (0–5.2) | 2.9 (0.6–8.2) | 1.9 (0.2–6.7) | 0 (0–3.5) |
Fatigue | 30.5 (21.9–40.2) | 45.2 (35.4–55.3) | 34.3 (25.3–44.2) | 31.4 (22.7–41.2) |
Grade 3 | 1.9 (0.2–6.7) | 3.8 (1.1–9.6) | 2.9 (0.6–8.1) | 1.0 (0–5.2) |
Headache | 22.9 (15.2–32.1) | 31.7 (22.9–41.6) | 24.8 (16.9–34.1) | 21.9 (14.4–31.0) |
Grade 3 | 2.9 (0.6–8.1) | 1.9 (0.2–6.8) | 1.0 (0–5.2) | 0 (0–3.5) |
Myalgia | 16.2 (9.7–24.7) | 38.5 (29.1–48.5) | 31.4 (22.7–41.2) | 14.3 (8.2–22.5) |
Grade 3 | 1.0 (0–5.2) | 2.9 (0.6–8.2) | 2.9 (0.6–8.1) | 1.0 (0–5.2) |
Nausea | 7.6 (3.3–14.5) | 9.6 (4.7–17.0) | 7.6 (3.3–14.5) | 7.6 (3.3–14.5) |
Grade 3 | 1.9 (0.2–6.7) | 1.9 (0.2–6.8) | 1.9 (0.2–6.7) | 1.0 (0–5.2) |
Shivering | 3.8 (1.0–9.5) | 9.6 (4.7–17.0) | 8.6 (4.0–15.6) | 3.8 (1.0–9.5) |
Grade 3 | 1.0 (0–5.2) | 1.9 (0.2–6.8) | 1.0 (0–5.2) | 0 (0–3.5) |
Fever (°C) | 1.0 (0–5.2) | 2.9 (0.6–8.2) | 1.9 (0.2–6.7) | 1.0 (0–5.2) |
>39°C | 0 (0–3.5) | 0 (0–3.5) | 0 (0–3.5) | 0 (0–3.5) |