Treatment groupa | |||||
---|---|---|---|---|---|
Vaccine Strain | QIV | LD QIV-AS | LD TIV-AS | TIV | |
Nb | 104 | 104 | 104 | 105 | |
A/Solomon Islands | |||||
GMT (95% CI) | Pre | 21.4 (16.1–28.4) | 22.2 (16.6–29.5) | 23.3 (17.5–31.0) | 18.4 (14.3–23.7) |
Post | 130.0 (106.1–159.4) | 150.6 (118.4–191.5) | 160.4 (129.1–199.3) | 133.8 (105.6–169.7) | |
SCR %(95% CI) | Post | 56.7 (46.7–66.4)*$ | 57.7 (47.6–67.3)* $ | 54.8 (44.7–64.6)* $ | 60.0 (50.0–69.4)* $ |
SPR %(95% CI) | Pre | 37.5 (28.2–47.5) | 42.3 (32.7–52.4) | 40.4 (30.9–50.5) | 35.2 (26.2–45.2) |
Post | 92.3 (85.4–96.6)* $ | 88.5 (80.7–93.9)* $ | 93.3 (86.6–97.3)* $ | 90.5 (83.2–95.3)* $ | |
SCF (95% CI) | Post | 6.1 (4.6–8.0)* | 6.8 (5.0–9.2)* | 6.9 (5.0–9.4)* | 7.3 (5.3–9.9)* |
A/Wisconsin | |||||
GMT (95% CI) | Pre | 29.3 (23.0–37.3) | 25.7 (19.8–33.3) | 30.7 (23.7–39.8) | 29.0 (22.5–37.4) |
Post | 162.1 (138.0–190.4) | 189.5 (158.9–226.0) | 197.9 (169.1–231.7) | 156.3 (127.5–191.6) | |
SCR %(95% CI) | Post | 60.6 (50.5–70.0)* $ | 66.3 (56.4–75.3)* $ | 64.4 (54.4–73.6)* $ | 59.0 (49.0–68.5)* $ |
SPR %(95% CI) | Pre | 51.0 (41.0–60.9) | 46.2 (36.3–56.2) | 53.8 (43.8–63.7) | 55.2 (45.2–65.0) |
Post | 97.1 (91.8–99.4)* $ | 98.1 (93.2–99.8)* $ | 100 (96.5–100)* $ | 96.2 (90.5–99.0)* $ | |
SCF (95% CI) | Post | 5.5 (4.4–6.9)* | 7.4 (5.8–9.4)* | 6.4 (5.0–8.3)* | 5.4 (4.1–7.0)* |
B/Malaysia | |||||
GMT (95% CI) | Pre | 32.2 (24.8–41.8) | 26.6 (20.2–35.0) | 23.2 (17.7–30.4) | 27.2 (20.6–35.8) |
Post | 192.8 (159.6–232.9) | 213.0 (174.0–260.9) | 187.0 (151.9–230.3) | 188.5 (150.0–237.0) | |
SCR %(95% CI) | Post | 57.7 (47.6–67.3)* $ | 65.4 (55.4–74.4)* $ | 56.7 (46.7–66.4)* $ | 59.0 (49.0–68.5)* $ |
SPR %(95% CI) | Pre | 51.0 (41.0–60.9) | 47.1 (37.2–57.2) | 42.3 (32.7–52.4) | 44.8 (35.0–54.8) |
Post | 97.1 (91.8–99.4)* $ | 97.1 (91.8–99.4)* $ | 96.2 (90.4–98.9)* $ | 93.3 (86.7–97.3)* $ | |
SCF (95% CI) | Post | 6.0 (4.7–7.7)* | 8.0 (6.1–10.5)* | 8.1 (5.9–11.0)* | 6.9 (5.2–9.3)* |
B/Jiangsu | |||||
GMT (95% CI) | Pre | 19.6 (15.6–24.8) | 19.5 (15.4–24.5) | 23.4 (18.3–29.7) | 19.2 (15.2–24.3) |
Post | 179.1 (151.4–211.9) | 158.3 (130.7–191.9) | 59.2 (47.3–74.0) | 43.4 (34.5–54.6) | |
SCR %(95% CI) | Post | 76.0 (66.6–83.8)* $ | 78.8 (69.7–86.2)* $ | 26.9 (18.7–36.5) | 19.0 (12.0–27.9) |
SPR %(95% CI) | Pre | 31.7 (22.9–41.6) | 38.5 (29.1–48.5) | 43.3 (33.6–53.3) | 39.0 (29.7–49.1) |
Post | 98.1 (93.2–99.8)* $ | 95.2 (89.1–98.4)* $ | 75.0 (65.6–83.0)* | 63.8 (53.9–73.0) | |
SCF (95% CI) | Post | 9.1 (7.2–11.5)* | 8.1 (6.6–10.0)* | 2.5 (2.1–3.0)* | 2.3 (1.9–2.6) |