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Table 1 Patient characteristics according to CRT

From: X4 viruses are frequently archived in patients with long-term HIV infection but do not seem to influence the “inflamm-aging” process

  R5 X4 p value
N patients 68 (58%) 50 (42%)  
Male gender (N,%) 52 (76%) 36 (72%) 0.6
Age (years, mean ± SD) 51.2 ± 5.6 50.6 ± 5.9 0.1
Foreign nationality (N,%) 1 (1.5%) 1 (2.0%) 0.8
HIV-1 non B subtype (N,%) 15 (22%) 7 (14%) 0.3
Risk factor (N,%)    
 - parenteral 44 (65%) 27 (54%)  
 - sexual 23 (34%) 21 (42%) 0.4
ART duration (years; median, IQR) 13 (9–16) 14 (10–16) 0.5
 - NRTIs 13 (9–16) 14 (10–16) 0.6
 - NNRTIs 4 (1–7) 4 (2–6) 1.0
 - PIs 7 (5–9) 6 (5–12) 0.5
Past use of mono- or bi-therapy (N,%) 43 (63%) 35 (70%) 0.8
Previous AIDS events (N,%) 7 (10%) 10 (20%) 0.2
Serious non-AIDS events (N,%) 19 (39%) 7 (14%) 0.07
HBsAg pos (N,%) 9 (13%) 4 (8%) 0.1
Anti-HCV pos (N,%) 51 (75%) 30 (60%) 0.1
pVL (log10 cp/ml;median, IQR) 3.2 (3.2-4.8) 4.1 (3.2-8.9) 0.1
Aviremic pts (N,%) 53 (78%) 36 (72%)  
CD4+ cell count (median, IQR)    
 - absolute (n/mmc) 658 (219–185) 558 (109–1219) 0.1
 - percentage (%) 31 (24–53) 28 (11–52) 0.1
Nadir CD4+ cell count    
 - absolute (median n/mmc;, IQR) 137 (90–616) 87 (27–382) 0.005
 - percentage (%) 11 (7–27) 8 (2–32) 0.01
  1. Legend: N = number, SD = standard deviation; IQR = InterQuartile Range; pVL: HIV-1 plasma viral load.