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Table 5 Association between maternal cytokine gene polymorphisms and antibody levels to P. falciparum antigens in mothers: multivariate analysis

From: Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns

Antibody response Maternal cytokine gene (n) Antibody levels (μg/ml)a(SD) P
IgM to AMA-1    
  IL-10 −1082 genotypes:   
   GG (47) 13.9 (3.3)  
   GA (223) 17.0 (3.5) 0.08 b
   AA (306) 20.0 (3.7)  
IgG to MSP-1    
  IL-4 −590 genotypes:   
   CC and CT (218) 49.0 (5.5)  
   TT (358) 32.8 (7.0) 0.02 c
IgG to MSP-2/3D7    
  IL-4 −590 genotypes:   
   CC and CT (218) 95.5 (10.3)  
   TT (358) 70.3 (11.9) 0.03 d
  IL-10 −1082 genotypes:   
   GG and GA (270) 68.2 (6.2)  
   AA (306) 92.9 (12.2) 0.04 d
IgG to MSP-2/FC27 IL-4 −590 genotypes:   
   CC (25) 147.7 (61.7)  
   CT (193) 98.0 (62.7)  
   TT (358) 85.4 (62.8) 0.02 b
IgG to GLURP-R2 e    
  IL-4 −590 genotypes:   
   CC (25) 23.2 (6.9)  
   CT and TT (551) 38.3 (7.6) 0.05 d
  IL-10 −1082 /IL-10 −819 /IL-10 −592 haplotypes:   
   No or 1 copy IL10-ATA (489) 38.6 (3.0)  
   2 copies IL10-ATA (87) 24.6 (7.6) 0.07 d
  1. a median value.
  2. b analysis adjusted on village.
  3. c analysis adjusted on presence of P. falciparum circulating parasites in mothers and presence of placental parasites.
  4. d analysis adjusted on presence of placental parasites.
  5. e 5 missing values.
  6. P values < 0.05 are in bold.
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BMC Infectious Diseases

ISSN: 1471-2334

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