Antibody response
|
Maternal cytokine gene (n)
|
Antibody levels (μg/ml)a(SD)
|
P
|
---|
IgM to AMA-1
| | | |
|
IL-10
−1082
genotypes:
| | |
|
GG (47)
|
13.9 (3.3)
| |
|
GA (223)
|
17.0 (3.5)
|
0.08 b
|
|
AA (306)
|
20.0 (3.7)
| |
IgG to MSP-1
| | | |
|
IL-4
−590
genotypes:
| | |
|
CC and CT (218)
|
49.0 (5.5)
| |
|
TT (358)
|
32.8 (7.0)
|
0.02
c
|
IgG to MSP-2/3D7
| | | |
|
IL-4
−590
genotypes:
| | |
|
CC and CT (218)
|
95.5 (10.3)
| |
|
TT (358)
|
70.3 (11.9)
|
0.03
d
|
|
IL-10
−1082
genotypes:
| | |
|
GG and GA (270)
|
68.2 (6.2)
| |
|
AA (306)
|
92.9 (12.2)
|
0.04
d
|
IgG to MSP-2/FC27
|
IL-4
−590
genotypes:
| | |
|
CC (25)
|
147.7 (61.7)
| |
|
CT (193)
|
98.0 (62.7)
| |
|
TT (358)
|
85.4 (62.8)
|
0.02
b
|
IgG to GLURP-R2 e
| | | |
|
IL-4
−590
genotypes:
| | |
|
CC (25)
|
23.2 (6.9)
| |
|
CT and TT (551)
|
38.3 (7.6)
|
0.05 d
|
|
IL-10
−1082
/IL-10
−819
/IL-10
−592
haplotypes:
| | |
|
No or 1 copy IL10-ATA (489)
|
38.6 (3.0)
| |
|
2 copies IL10-ATA (87)
|
24.6 (7.6)
|
0.07 d
|
-
a median value.
-
b analysis adjusted on village.
-
c analysis adjusted on presence of P. falciparum circulating parasites in mothers and presence of placental parasites.
-
d analysis adjusted on presence of placental parasites.
-
e 5 missing values.
-
P values < 0.05 are in bold.