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Table 4 Association between maternal cytokine gene polymorphisms and newborns’ biological parameters: multivariate analysis

From: Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns

Maternal cytokine gene (n) Haemoglobin (g/dl) (SD)a P b Anaemia OR [CI95]c P d
IL-10 −1082 genotypes:     
 GG (47) 15.1 (0.3)    
 GA and AA (529) 14.6 (0.3) 0.07 OR GA and AA vs GG = 1.81 [0.98-3.32] 0.06
IL-10 −819 genotypes:     
 CC (191) 14.8 (0.2)    
 CT and TT (385) 14.6 (0.2) 0.14 OR CT and TT vs CC = 1.46 [1.02-2.10] 0.04
IL-10 −592 genotypes:     
 CC (191) 14.7 (0.1)    
 CA and AA (385) 14.4 (0.2) 0.13 OR CA and AA vs CC = 1.36 [0.95-1.95] 0.09
IL-10 −1082 /IL-10 −819 /IL-10 −592 haplotypes:     
 No IL10-ATA (196) 14.8 (0.2)    
 1 or 2 copies IL10-ATA (380) 14.6 (0.2) 0.13 OR 1 or 2 copies IL10-ATA vs. no IL10-ATA = 1.45 [1.02-2.08] 0.04
  1. a 5 missing values.
  2. b analysis adjusted on maternal anaemia (Hb < 11 g/dl) and low birthweight (< 2500 g).
  3. c newborn’s anaemia defined as Hb < 15 g/dl.
  4. d analysis adjusted on maternal anaemia and age.
  5. P values < 0.05 are in bold.
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BMC Infectious Diseases

ISSN: 1471-2334

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