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Table 3 Association between maternal cytokine gene polymorphisms and mothers’ biological parameters: multivariate analysis

From: Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns

Maternal cytokine gene (n) Haemoglobin (g/dl) (SD)a P b Anaemia OR [CI95]c P b P. falciparumplacenta infection OR [CI95]d P e
IL-4 −590 genotypes:       
 CC (25) 11.2 (0.3)   1    
 CT (193) 11.1 (0.3) 0.88 1.13 [0.48-2.65] 0.77   
 TT (358) 11.3 (0.3) 0.65 0.87 [0.38-1.98] 0.73 OR CT and TT vs. CC = 0.36 [0.14-0.93] 0.03
IL-4 +33 genotypes:       
 CC (145) 11.3 (0.2)      
 CT and TT (431) 11.6 (0.1) 0.03 OR CT and TT vs. CC = 0.66 [0.44-0.97] 0.04 OR CT and TT vs. CC = 0.54 [0.31-0.94] 0.03
IL-4 −590 /IL-4 +33 haplotypes:       
 No IL4-TT (145) 11.3 (0.2)      
 1 or 2 copies IL4-TT (431) 11.6 (0.1) 0.03 OR 1 or 2 copies IL4-TT vs. no IL4-TT = 0.66 [0.44-0.97] 0.04 OR 1 or 2 copies IL4-TT vs. no IL4-TT = 0.54 [0.31-0.94] 0.03
IL-10 −1082 genotypes:       
 GG (47) 11.4 (0.2)   1    
 GA (223) 11.3 (0.2) 0.53 1.01 [0.52-1.94] 0.98   
 AA (306) 11.3 (0.2) 0.59 1.23 [0.65-2.34] 0.52 OR AA vs GG and GA = 1.95 [1.11-3.42] 0.02
  1. a 3 missing values.
  2. b analysis adjusted on village.
  3. c anaemia defined as Hb < 11 g/dl.
  4. d 13 missing values.
  5. e analysis adjusted on parity and village.
  6. P values < 0.05 are in bold.
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BMC Infectious Diseases

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