Table 1 Comparison of 110 patients with asymptomatic bacteriuria to 177 patients with symptomatic urinary tract infection due to E. coli
Variable | Asymptomatic bacteriuria (n = 110) | Symptomatic urinary tract infection (n = 177) | p value | Adjusted odds ratio (95% CI)* |
|---|---|---|---|---|
n (%) | n (%) | |||
Gender (male) | 19 (17) | 43 (24) | 0.2 | |
Age (years, median, range) | 67 (20, 100) | 64 (19, 101) | 0.1 | |
Race (white) | 68 (62) | 101 (57) | 0.4 | |
Body mass index (kg/m2, mean, ±SD) | 28.9 (±8.4) | 28.9 (±9.9) | 1.0 | |
Diabetes mellitus | 39 (36) | 53 (30) | 0.3 | |
Renal insufficiency (Cr > 1.5 mg/dl) | 23 (21) | 37 (21) | 1.0 | |
Any malignancy | 28 (26) | 44 (25) | 0.9 | |
Any transplant | 3 (3) | 9 (5) | 0.3 | |
Neutropenia at time of bacteriuria (ANC <1000/ul) | 0 | 7 (4) | 0.046 | |
Pregnancy | 5 (5) | 8 (6) | 1.0 | |
Congestive heart failure | 26 (24) | 24 (14) | 0.03 | |
Myocardial infarction | 23 (21) | 18 (10) | 0.01 | |
Chronic pulmonary disease | 25 (23) | 24 (14) | 0.045 | 2.1 (1.04-4.1) |
Peripheral vascular disease | 9 (8) | 5 (3) | 0.04 | |
Oral steroid medication | 6 (5) | 15 (8) | 0.3 | |
Dementia | 15 (14) | 11 (6) | 0.03 | 2.4 (1.02-5.8) |
History of cerebrovascular accident | 24 (22) | 36 (20) | 0.8 | |
Hemi- or paraplegia | 13 (12) | 14 (8) | 0.3 | |
Functional or anatomical urinary tract abnormalities | 31 (28) | 54 (31) | 0.7 | |
Voiding dysfunction | 26 (24%) | 54 (31%) | 0.2 | |
Benign prostatic hyperplasia (n = 62) | 3/19 (16) | 15/43 (35) | 0.1 | |
History of urogenital surgery | 30 (27) | 61 (34) | 0.8 | |
Urological procedure this admission | 0 | 5 (3) | 0.2 | |
Charlson comorbidity index (mean, ±SD) | 3.1 (±2.6) | 2.8 (±2.8) | 0.2 | |
McCabe severity-of-illness score (median, range) | 1 (1, 2) | 1 (1, 3) | 0.2 | |
Cystitis | - | 70 (39) | - | |
Pyelonephritis | - | 107 (62) | - | |
Sepsis | 38 (35) | 108 (61) | <0.001 | |
Sepsis-induced hypotension | 7 (6) | 41 (23) | <0.001 | |
Community-acquired bacteriuria | 75 (68) | 127 (72) | 0.5 | |
Urinary catheter-associated bacteriuria | 22 (20) | 30 (17) | 0.5 | |
Urinalysis with pyuria (>10 WBC/hpf) | 65 (63) | 121 (74) | 0.1 | |
Isolate resistant to ciprofloxacin | 57 (32%) | 41 (37%) | 0.4 | |
Isolate resistant to trimethoprim/ sulfamethoxazole | 45 (25%) | 32 (29%) | 0.5 | |
Outcomes | ||||
Pathogen-directed antibiotic treatment | 89 (81) | 168 (95) | <0.001 | |
Length of hospital stay (mean, ±SD) | 5.5 (±7.7) | 6.6 (±7.5) | 0.2 | |
In-hospital mortality | 4 (3.6) | 8 (5) | 0.5 |