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Table 3 Association between time-varying factors and incidence of bacterial vaginosis recurrence among 440 female sex workers followed-up in a microbicide trial: hazard ratios (unadjusted vs. adjusted for the study site)

From: Behavioural and medical predictors of bacterial vaginosis recurrence among female sex workers: longitudinal analysis from a randomized controlled trial

Time-varying Factors Incidence rate of BV recurrence (per 100 person-months) by exposure level (NR*/person-months) HR§ and 95% CI p-value HR§ (adjusted for study site) with 95% CI p-value
Number of sexual partners/past 7 days (continuous) - 0.99 (0.98-0.99) 0.0142 0.99 (0.99-1.00) 0.4145
CCU‡ with primary partner in the past 7 days:      
   yes 18.8 (73/387.27) 0.58 (0.42-0.80) 0.0010 0.67 (0.49- 0.93) 0.0153
   No (ref.) 32.3 (113/349.28) 1.00 - - 1.00 - -
   No primary partner or no sexual act with him 17.6 (183/1039.67) 0.54 (0.42-0.71) <0.0001 0.69 (0.53- 0.88) 0.0032
CCU‡ with other partners in the past 7 days:      
   yes 18.8 (319/1457.60) 0.84 (0.41-1.72) 0.6353 1.33 (0.58-2.20) 0.7269
   No (ref.) 24.9 (6/24.07) 1.00 - - 1.00 - -
   No sexual act with other partners 16.0 (44/274.95) 0.62 (0.29-1.36) 0.2380 0.96 (0.47-1.97) 0.9077
Oral sex with primary partner/past 30 days      
   yes 45.2 (11/24.35) 2.07 (1.24-3.47) 0.0054 1.10 (0.64 - 1.90) 0.7298
   No 21.7 (324/1495.87) 1.00 - - 1.00 - -
   No primary partner 13.8 (36/261.38) 0.62 (0.42-0.93) 0.0195 0.92 (0.65-1.28) 0.6094
Oral sex without condom with primary partner/past 30 days      
   yes 46.8 (9/19.22) 2.24 (1.36-3.70) 0.0015 1.20 (0.71-2.03) 0.4934
   No 21.7 (326/1501.00) 1.00 - - 1.00 - -
   No primary partner 13.8 (36/261.38) 0.62 (0.42-0.92) 0.0190 0.92 (0.66-1.28) 0.6183
Oral sex with other partners/past 30 days      
   yes 35.6 (17/47.72) 1.70 (1.16-2.50) 0.0062 0.86 (0.56-1.32) 0.4930
   No 20.6 (353/1711.97) 1.00 - - 1.00 - -
Oral sex without condom with other partner/past 30 days      
   yes 45.1 (4/8.87) 2.23 (0.90-5.52) 0.0824 1.19 (0.46-3.04) 0.7193
   No 20.9 (366/1750.82) 1.00 - - 1.00 - -
Gonorrhea in the at-risk-period      
   Present 24.5 (17/69.42) 1.18 (0.75-1.86) 0.4813 1.45 (0.87-2.416) 0.1482
   Absent 20.7 (354/1713.70) 1.00 - - 1.00 - -
Chlamydia in the at-risk-period      
   Present 16.1 (12/74.40) 0.77 (0.43-1.37) 0.3688 1.12 (0.67-1.87) 0.6720
   Absent 21.0 (359/1708.72) 1.00 - - 1.00 - -
Trichomoniasis in the at-risk-period      
   Present 15.7 (8/50.85) 0.73 (0.33-1.61) 0.4393 0.80 (0.37-1.71) 0.5589
   Absent 20.9 (363/1732.27) 1.00 - - 1.00 - -
Candidiasis in the at-risk-period      
   Present 15.6 (86/552.65) 0.68 (0.53-0.87) 0.0025 0.69 (0.53-0.91) 0.0095
   Absent 23.2 (285/1230.47) 1.00 - - 1.00 - -
  1. *NR =number of recurrences; § HR=Hazard ratio; CI=Confidence interval; ‡ CCU=Consistent condom use (100% of sexual acts).