Table 3 Association between time-varying factors and incidence of bacterial vaginosis recurrence among 440 female sex workers followed-up in a microbicide trial: hazard ratios (unadjusted vs. adjusted for the study site)
Time-varying Factors | Incidence rate of BV recurrence (per 100 person-months) by exposure level (NR*/person-months) | HR§ and 95% CI¶ | p-value | HR§ (adjusted for study site) with 95% CI¶ | p-value |
|---|---|---|---|---|---|
Number of sexual partners/past 7 days (continuous) | - | 0.99 (0.98-0.99) | 0.0142 | 0.99 (0.99-1.00) | 0.4145 |
CCU‡ with primary partner in the past 7 days: | |||||
yes | 18.8 (73/387.27) | 0.58 (0.42-0.80) | 0.0010 | 0.67 (0.49- 0.93) | 0.0153 |
No (ref.) | 32.3 (113/349.28) | 1.00 - | - | 1.00 - | - |
No primary partner or no sexual act with him | 17.6 (183/1039.67) | 0.54 (0.42-0.71) | <0.0001 | 0.69 (0.53- 0.88) | 0.0032 |
CCU‡ with other partners in the past 7 days: | |||||
yes | 18.8 (319/1457.60) | 0.84 (0.41-1.72) | 0.6353 | 1.33 (0.58-2.20) | 0.7269 |
No (ref.) | 24.9 (6/24.07) | 1.00 - | - | 1.00 - | - |
No sexual act with other partners | 16.0 (44/274.95) | 0.62 (0.29-1.36) | 0.2380 | 0.96 (0.47-1.97) | 0.9077 |
Oral sex with primary partner/past 30 days | |||||
yes | 45.2 (11/24.35) | 2.07 (1.24-3.47) | 0.0054 | 1.10 (0.64 - 1.90) | 0.7298 |
No | 21.7 (324/1495.87) | 1.00 - | - | 1.00 - | - |
No primary partner | 13.8 (36/261.38) | 0.62 (0.42-0.93) | 0.0195 | 0.92 (0.65-1.28) | 0.6094 |
Oral sex without condom with primary partner/past 30 days | |||||
yes | 46.8 (9/19.22) | 2.24 (1.36-3.70) | 0.0015 | 1.20 (0.71-2.03) | 0.4934 |
No | 21.7 (326/1501.00) | 1.00 - | - | 1.00 - | - |
No primary partner | 13.8 (36/261.38) | 0.62 (0.42-0.92) | 0.0190 | 0.92 (0.66-1.28) | 0.6183 |
Oral sex with other partners/past 30 days | |||||
yes | 35.6 (17/47.72) | 1.70 (1.16-2.50) | 0.0062 | 0.86 (0.56-1.32) | 0.4930 |
No | 20.6 (353/1711.97) | 1.00 - | - | 1.00 - | - |
Oral sex without condom with other partner/past 30 days | |||||
yes | 45.1 (4/8.87) | 2.23 (0.90-5.52) | 0.0824 | 1.19 (0.46-3.04) | 0.7193 |
No | 20.9 (366/1750.82) | 1.00 - | - | 1.00 - | - |
Gonorrhea in the at-risk-period | |||||
Present | 24.5 (17/69.42) | 1.18 (0.75-1.86) | 0.4813 | 1.45 (0.87-2.416) | 0.1482 |
Absent | 20.7 (354/1713.70) | 1.00 - | - | 1.00 - | - |
Chlamydia in the at-risk-period | |||||
Present | 16.1 (12/74.40) | 0.77 (0.43-1.37) | 0.3688 | 1.12 (0.67-1.87) | 0.6720 |
Absent | 21.0 (359/1708.72) | 1.00 - | - | 1.00 - | - |
Trichomoniasis in the at-risk-period | |||||
Present | 15.7 (8/50.85) | 0.73 (0.33-1.61) | 0.4393 | 0.80 (0.37-1.71) | 0.5589 |
Absent | 20.9 (363/1732.27) | 1.00 - | - | 1.00 - | - |
Candidiasis in the at-risk-period | |||||
Present | 15.6 (86/552.65) | 0.68 (0.53-0.87) | 0.0025 | 0.69 (0.53-0.91) | 0.0095 |
Absent | 23.2 (285/1230.47) | 1.00 - | - | 1.00 - | - |