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Table 4 T cell response of donors to predicted and conserved T cell epitopes encompassing entire HA protein

From: T cell memory to evolutionarily conserved and shared hemagglutinin epitopes of H1N1 viruses: a pilot scale study

Donor ID (age/ gender) HLA-DRB1, 3, 4, and 5 alleles CD4+ epitopes on HA protein
HA1 (1–329 a.a) HA2 (330–561 a.a)
19-33 99-113 104-119 315-329 319-333 377-391 413-427 421-435 426-440 510-524 511-525 518-532 531-545
D1 (22/M) DRB1*13             X  
  DRB1*14              
  DRB3*52              
D2 (22/M) DRB1*04,             X X
  DRB1*15              
  DRB4*53,              
  DRB5*51              
D3 (23/F) DRB1*04,              
  DRB1*15              
  DRB4*53,              
  DRB5*51              
D4 (25/M) DRB1*07             X X
  DRB3*52              
D5 (23/M) DRB1*03      X   X      X X
  DRB3*52              
D6 (27/M) DRB1*04,             X X
  DRB1*17              
  DRB3*52,              
  DRB4*53              
D7 (30/F) DRB1*08,       X     X X X X
  DRB1*15              
  DRB5*51              
D8 (34/M) DRB1*07           X X   
  DRB4*53              
D9 (51/F) DRB1*07,       X   X X    X  
  DRB1*17              
  DRB3*52,              
  DRB4*53              
D10 (53/M) DRB1*07,    X X X X X X X X X X X
  DRB1*13              
  DRB4*53              
D11 (53/F) DRB1*07,     X X    X X X X X X
  DRB1*17              
  DRB3*52,              
  DRB4*53              
D12 (60/F) DRB1*03           X X X X
  DRB4*52              
D13 (66/F) DRB1*15             X  
  DRB4*53,              
  DRB5*51              
D14 (66/M) DRB1*04 X   X X X X      X X X
  DRB3*52,              
  DRB4*53              
  1. X: denotes positive IFN-γ secretions.
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