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Table 2 Predicted DRB1 alleles and other DRB haplotypes as potential MHC II molecules to CD4+ HA T cell epitopes

From: T cell memory to evolutionarily conserved and shared hemagglutinin epitopes of H1N1 viruses: a pilot scale study

T- cell epitopes Position on HA protein Predicted DRB1 alleles Predicted alleles of other DR haplotypes (DRB3, 4 and 5)
Alleles predicted to bind strongly with each epitope based on threshold binding affinity, <50 nM. Alleles predicted to bind weakly with each epitope based on threshold binding affinity, >50 nM to <500 nM. Alleles predicted to bind strongly with each epitope based on threshold binding affinity, <50 nM. Alleles predicted to bind weakly with each epitope based on threshold binding affinity, >50 nM to <500 nM.
HA1 19-33 DRB1*0701,DRB1*1201, DRB1*1301 DRB1*0101,DRB1*0801, DRB5*0202 DRB3*0201,DRB3*0301
   DRB1*1401   
HA1 99-113 - DRB1*0101,DRB1*0701, DRB5*0202 DRB3*0201,DRB4*0101
   DRB1* 1001   DRB5*0101
HA1 104-119 - DRB1*0701,DRB1*1201 - DRB5*0101,DRB5*0202
HA1 315-329 DRB1*0101,DRB1*0801, DRB1*0401,DRB1*0404, DRB3*0201,DRB5*0202 DRB3*0301,DRB4*0101
  DRB1*1201 DRB1*0701,DRB1*0901,   DRB5*0101
   DRB1*1001,DRB1*1101,   
   DRB1*1301,DRB1*1401,   
   DRB1*1501   
HA1 317-331 DRB1*0801,DRB1*1201 DRB1*0101,DRB1*0401, DRB5*0202 DRB3*0201,DRB3*0301
   DRB1*0701,DRB1*1101,   DRB4*0101,DRB5*0101
   DRB1*1301,DRB1*1401,   
   DRB1*1501   
HA1 319-333 DRB1*1201 DRB1*0701,DRB1*0801, DRB5*0202 DRB3*0201,DRB4*0101
   DRB1*1301,DRB1*1501   
HA1 325-339 DRB1*0101 DRB1*0701,DRB1*1201, - DRB5*0101,DRB5*0202
   DRB1*1501   
HA2 377-391 - DRB1*0801,DRB1*1201, - DRB5*0202
   DRB1*1301   
HA2 382-396 - DRB1*0101,DRB1*0401, DRB5*0202 DRB3*0201
   DRB1*0801,DRB1*1201   
HA2 413-427 - DRB1*0101,DRB1*0401, - DRB3*0301,DRB5*0202
   DRB1*0404,DRB1*0701,   
   DRB1*1001,DRB1*1201,   
   DRB1*1301,DRB1*1501   
HA2 419-433 - DRB1*0101 - DRB3*0301,DRB5*0202
HA2 420-434 - DRB1*0101,DRB1*0401, - DRB3*0201,DRB4*0101
   DRB1*0404,DRB1*1201   DRB5*0202
HA2 421-435 DRB1*0101 DRB1*0401,DRB1*0404, DRB5*0202 DRB3*0201,DRB3*0301
   DRB1*1001,DRB1*1101,   DRB4*0101
   DRB1*1201,DRB1*1301,   
   DRB1*1501   
HA2 426-440 DRB1*0101 DRB1*0301,DRB1*0401, - DRB3*0201,DRB3*0301
   DRB1*1001,DRB1*1201,   DRB4*0101,DRB5*0202
   DRB1*1301   
HA2 510-524 DRB1*0101,DRB1*0404, DRB1*0401,DRB1*0901, DRB5*0202 DRB3*0201,DRB3*0301
  DRB1*0701,DRB1*0801, DRB1*1101,DRB1*1301   DRB4*0101,DRB5*0101
  DRB1*1001,DRB1*1201    
HA2 511-525 DRB1*0101,DRB1*0401, DRB1*1101 DRB3*0201,DRB3*0301 DRB4*0101,DRB5*0101
  DRB1*0404,DRB1*0701,   DRB5*0202  
  DRB1*0801,DRB1*0901,    
  DRB1*1001    
HA2 518-532 - DRB1*0101,DRB1*0701, - DRB3*0201,DRB3*0301
   DRB1*1001,DRB1*1201   DRB5*0202
HA2 531-545 DRB1*0101 DRB1*0401,DRB1*0404, - DRB3*0301,DRB5*0101
   DRB1*0701,DRB1*0901,   DRB5*0202
   DRB1*1001,DRB1*1201,   
   DRB1*1501   
  1. NetMHCIIPan tool was used to predict binding affinity of each epitope with DRB1 alleles and other alleles of DR haplotypes (binding affinity: <50 nM (strong) and >50 nM to <500 nM (weak)). Bold faced epitopes were used in in vitro assays.