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Table 2 Predicted DRB1 alleles and other DRB haplotypes as potential MHC II molecules to CD4+ HA T cell epitopes

From: T cell memory to evolutionarily conserved and shared hemagglutinin epitopes of H1N1 viruses: a pilot scale study

T- cell epitopes Position on HA protein

Predicted DRB1 alleles

Predicted alleles of other DR haplotypes (DRB3, 4 and 5)

Alleles predicted to bind strongly with each epitope based on threshold binding affinity, <50 nM.

Alleles predicted to bind weakly with each epitope based on threshold binding affinity, >50 nM to <500 nM.

Alleles predicted to bind strongly with each epitope based on threshold binding affinity, <50 nM.

Alleles predicted to bind weakly with each epitope based on threshold binding affinity, >50 nM to <500 nM.

HA1 19-33

DRB1*0701,DRB1*1201, DRB1*1301

DRB1*0101,DRB1*0801,

DRB5*0202

DRB3*0201,DRB3*0301

  

DRB1*1401

  

HA1 99-113

-

DRB1*0101,DRB1*0701,

DRB5*0202

DRB3*0201,DRB4*0101

  

DRB1* 1001

 

DRB5*0101

HA1 104-119

-

DRB1*0701,DRB1*1201

-

DRB5*0101,DRB5*0202

HA1 315-329

DRB1*0101,DRB1*0801,

DRB1*0401,DRB1*0404,

DRB3*0201,DRB5*0202

DRB3*0301,DRB4*0101

 

DRB1*1201

DRB1*0701,DRB1*0901,

 

DRB5*0101

  

DRB1*1001,DRB1*1101,

  
  

DRB1*1301,DRB1*1401,

  
  

DRB1*1501

  

HA1 317-331

DRB1*0801,DRB1*1201

DRB1*0101,DRB1*0401,

DRB5*0202

DRB3*0201,DRB3*0301

  

DRB1*0701,DRB1*1101,

 

DRB4*0101,DRB5*0101

  

DRB1*1301,DRB1*1401,

  
  

DRB1*1501

  

HA1 319-333

DRB1*1201

DRB1*0701,DRB1*0801,

DRB5*0202

DRB3*0201,DRB4*0101

  

DRB1*1301,DRB1*1501

  

HA1 325-339

DRB1*0101

DRB1*0701,DRB1*1201,

-

DRB5*0101,DRB5*0202

  

DRB1*1501

  

HA2 377-391

-

DRB1*0801,DRB1*1201,

-

DRB5*0202

  

DRB1*1301

  

HA2 382-396

-

DRB1*0101,DRB1*0401,

DRB5*0202

DRB3*0201

  

DRB1*0801,DRB1*1201

  

HA2 413-427

-

DRB1*0101,DRB1*0401,

-

DRB3*0301,DRB5*0202

  

DRB1*0404,DRB1*0701,

  
  

DRB1*1001,DRB1*1201,

  
  

DRB1*1301,DRB1*1501

  

HA2 419-433

-

DRB1*0101

-

DRB3*0301,DRB5*0202

HA2 420-434

-

DRB1*0101,DRB1*0401,

-

DRB3*0201,DRB4*0101

  

DRB1*0404,DRB1*1201

 

DRB5*0202

HA2 421-435

DRB1*0101

DRB1*0401,DRB1*0404,

DRB5*0202

DRB3*0201,DRB3*0301

  

DRB1*1001,DRB1*1101,

 

DRB4*0101

  

DRB1*1201,DRB1*1301,

  
  

DRB1*1501

  

HA2 426-440

DRB1*0101

DRB1*0301,DRB1*0401,

-

DRB3*0201,DRB3*0301

  

DRB1*1001,DRB1*1201,

 

DRB4*0101,DRB5*0202

  

DRB1*1301

  

HA2 510-524

DRB1*0101,DRB1*0404,

DRB1*0401,DRB1*0901,

DRB5*0202

DRB3*0201,DRB3*0301

 

DRB1*0701,DRB1*0801,

DRB1*1101,DRB1*1301

 

DRB4*0101,DRB5*0101

 

DRB1*1001,DRB1*1201

   

HA2 511-525

DRB1*0101,DRB1*0401,

DRB1*1101

DRB3*0201,DRB3*0301

DRB4*0101,DRB5*0101

 

DRB1*0404,DRB1*0701,

 

DRB5*0202

 
 

DRB1*0801,DRB1*0901,

   
 

DRB1*1001

   

HA2 518-532

-

DRB1*0101,DRB1*0701,

-

DRB3*0201,DRB3*0301

  

DRB1*1001,DRB1*1201

 

DRB5*0202

HA2 531-545

DRB1*0101

DRB1*0401,DRB1*0404,

-

DRB3*0301,DRB5*0101

  

DRB1*0701,DRB1*0901,

 

DRB5*0202

  

DRB1*1001,DRB1*1201,

  
  

DRB1*1501

  
  1. NetMHCIIPan tool was used to predict binding affinity of each epitope with DRB1 alleles and other alleles of DR haplotypes (binding affinity: <50 nM (strong) and >50 nM to <500 nM (weak)). Bold faced epitopes were used in in vitro assays.
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