T cell memory to evolutionarily conserved and shared hemagglutinin epitopes of H1N1 viruses: a pilot scale study

BMC Infectious Diseases

Table 1 Predicted CD4+ HA T cell epitopes of A(H1N1)pdm09 viruses and their conservancy in seasonal H1N1 (1977–2009) viruses

Predicted CD4+ T- cell epitopes (15 a. a) (epitope position)	% of predicted epitope conservancy in seasonal H1N1(1977–2009) HA proteins	% seasonal H1N1(1977–2009) isolates with each of the conserved epitope	% A(H1N1)pdm09 (2009–2010) isolates with each of the conserved epitope
VLEKNVTVTHSVNLL	100	100	99
(HA1 19–33)
EELREQLSSVSSFER	100	100	99
(HA1 99–113)
QLSSVSSFERFEIFP	100	100	99
(104–119)
ATGLRNIPSIQSRGL	93	97	98
(HA1 315–329)
GLRNIPSIQSRGLFG	100	97	100
(HA1 317–331)
RNIPSIQSRGLFGAI	100	97	98
(HA1 319–333)
QSRGLFGAIAGFIEG	100	100	100
(HA1 325–339)
NKVNSVIEKMNTQFT	100	96	99
(HA2 377–391)
VIEKMNTQFTAVGKE	100	96	99
(HA2 382–396)
DGFLDIWTYNAELLV	100	96	99
(HA2 413–427)
WTYNAELLVLLENER	100	99	100
(HA2 419–433)
TYNAELLVLLENERT	100	99	100
(HA2 420–434)
YNAELLVLLENERTL	100	100	100
(HA2 421–435)
LVLLENERTLDYHDS	100	98	100
(HA2 426–440)
I YQILAIYSTVASSL	93	100	100
(HA2 510–524)
YQILAIYSTVASSLV	100	100	100
(HA2 511–525)
STVASSLVL L VSLGA	93	100	98
(HA2 518–532)
GAISFWMCSNGSLQC	100	98	99
(HA2 531–545)