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Table 5 Contribution of Class I and II HLA alleles to development of ACL in a Southern Brazilian population

From: Association between HLA genes and American cutaneous leishmaniasis in endemic regions of Southern Brazil

Allele

ACL

Controls (n = 260)

P-value

Pc-value

OR

95%CI

 

n

F%

n

F %

    

ACL overall (n = 169)

        

   HLA-B*45

0

-

12

2.3

0.0046

0.1426

-

-

   HLA-DRB1*13

51

15.1

54

10.4

0.0431

0.6465

1.53

1.01-2.31

ACL (group 1; n = 136)

        

   HLA-DRB1*13

44

16.2

54

10.4

0.0228

0.3420

1.66

1.08-2.55

   HLA-B*35

53

19.5

68

13.1

0.0218

0.6758

1.67

1.08-2.29

   HLA-B*44

38

14.0

46

8.9

0.0290

0.8990

1.67

1.05-2.64

   HLA-B*45

0

-

12

2.3

0.0107

0.3317

-

-

ACL (group 1A; n = 118)

        

   HLA-B*44

35

14.8

46

8.9

0.0160

0.4969

1.79

1.12-2.87

   HLA-B*45

0

-

12

2.3

0.0231

0.0225

-

-

   HLA-DRB1*13

38

16.1

54

10.4

0.0152

0.2280

1.65

1.06-2.59

ACL (group 2; n = 15)

        

   HLA-B*27

3

10.0

8

1.5

0.0180

0.5580

7.11

1.78-28.33

ACL (group 3B; n = 7)

        

   HLA-B*52

3

21.4

11

2.1

0.0044

0.1360

12.61

3.08-51.66

ACL (group 4; n = 22)

        

   HLA-B*49

4

9.1

8

1.5

0.0101

0.3131

6.4

1.8-22.17

  1. n = number of times the allele occurs; F = Allele frequency; P-value = calculated by Fisher’s exact test; Pc-value = value of P corrected by Bonferroni correction; OR = odds ratio; 95%CI = 95% confidence interval.