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Table 5 Contribution of Class I and II HLA alleles to development of ACL in a Southern Brazilian population

From: Association between HLA genes and American cutaneous leishmaniasis in endemic regions of Southern Brazil

Allele ACL Controls (n = 260) P-value Pc-value OR 95%CI
  n F% n F %     
ACL overall (n = 169)         
   HLA-B*45 0 - 12 2.3 0.0046 0.1426 - -
   HLA-DRB1*13 51 15.1 54 10.4 0.0431 0.6465 1.53 1.01-2.31
ACL (group 1; n = 136)         
   HLA-DRB1*13 44 16.2 54 10.4 0.0228 0.3420 1.66 1.08-2.55
   HLA-B*35 53 19.5 68 13.1 0.0218 0.6758 1.67 1.08-2.29
   HLA-B*44 38 14.0 46 8.9 0.0290 0.8990 1.67 1.05-2.64
   HLA-B*45 0 - 12 2.3 0.0107 0.3317 - -
ACL (group 1A; n = 118)         
   HLA-B*44 35 14.8 46 8.9 0.0160 0.4969 1.79 1.12-2.87
   HLA-B*45 0 - 12 2.3 0.0231 0.0225 - -
   HLA-DRB1*13 38 16.1 54 10.4 0.0152 0.2280 1.65 1.06-2.59
ACL (group 2; n = 15)         
   HLA-B*27 3 10.0 8 1.5 0.0180 0.5580 7.11 1.78-28.33
ACL (group 3B; n = 7)         
   HLA-B*52 3 21.4 11 2.1 0.0044 0.1360 12.61 3.08-51.66
ACL (group 4; n = 22)         
   HLA-B*49 4 9.1 8 1.5 0.0101 0.3131 6.4 1.8-22.17
  1. n = number of times the allele occurs; F = Allele frequency; P-value = calculated by Fisher’s exact test; Pc-value = value of P corrected by Bonferroni correction; OR = odds ratio; 95%CI = 95% confidence interval.