Association between HLA genes and American cutaneous leishmaniasis in endemic regions of Southern Brazil

BMC Infectious Diseases

Table 1 Frequency of HLA-A, -B and -DRB1 alleles in the ACL group versus the control group

	ACL (n = 169)		Controls (n = 260)							ACL (n = 169)		Controls (n = 260)
Allele	n	F %	n	*F %*	P -value	Pc-value	OR	95%CI	Allele	n	F%	n	F%	P -value	Pc-value	OR	95%CI
HLA – A*									HLA-B*
01	37	10.9	47	9.0	ns	-			07	20	5.9	38	7.3	ns	-
02	95	28.1	127	24.4	ns	-			08	16	4.7	34	6.5	ns	-
03	30	8.8	56	10.8	ns	-			13	1	0.3	9	1.7	ns	-
11	23	6.8	26	5.0	ns	-			14	15	4.4	22	4.2	ns	-
23	18	5.3	22	4.2	ns	-			15	26	7.7	48	9.2	ns	-
24	37	10.9	62	11.9	ns	-			18	17	5.0	36	6.9	ns	-
25	4	1.2	13	2.5	ns	-			27	7	2.1	8	1.5	ns	-
26	11	3.2	18	3.5	ns	-			35	58	17.2	68	13.1	ns	-
29	9	2.6	28	5.4	ns	-			37	1	0.3	5	1.0	ns	-
30	11	3.2	25	4.8	ns	-			38	10	3.0	15	2.9	ns	-
31	18	5.3	19	3.7	ns	-			39	13	3.9	18	3.5	ns	-
32	8	2.3	16	3.1	ns	-			40	18	5.3	16	3.1	ns	-
33	5	1.5	15	2.9	ns	-			41	2	0.6	6	1.2	ns	-
34	3	0.9	5	1.0	ns	-			42	2	0.6	6	1.2	ns	-
36	2	0.6	2	0.4	ns	-			44	43	12.7	46	8.9	ns	-
39	1	0.3	-	-	ns	-			45	0	-	12	2.3	0.0046	0.1426	-	-
66	3	0.9	1	0.2	ns	-			46	0	-	4	0.8	ns	-
68	19	5.62	35	6.7	ns	-			47	0	-	1	0.2	ns	-
74	4	1.9	3	0.6	ns	-			48	3	0.9	2	0.4	ns	-
HLA-DRB1*									49	8	2.4	8	1.5	ns	-
01	23	6.8	42	8.1	ns	-			50	8	2.4	14	2.7	ns	-
03	32	9.5	61	11.7	ns	-			51	29	8.6	44	8.5	ns	-
04	40	11.8	56	10.8	ns	-			52	10	3.0	11	2.1	ns	-
07	39	11.5	67	12.9	ns	-			53	7	2.1	8	1.5	ns	-
08	26	7.7	30	5.8	ns	-			54	1	0.3	3	0.6	ns	-
09	4	1.2	4	0.8	ns	-			55	8	2.4	12	2.3	ns	-
10	5	1.5	10	1.9	ns	-			56	2	0.6	1	0.2	ns	-
11	45	13.3	81	15.6	ns	-			57	7	2.1	12	2.3	ns	-
12	3	0.9	10	1.9	ns	-			58	6	1.8	10	1.9	ns	-
13	51	15.1	54	10.4	0.0431	0.6465	1.53	1.01-2.31	73	0	-	1	0.2	ns	-
14	19	5.6	40	7.7	ns	-			81	0	-	2	3.9	ns	-
15	34	10.1	44	8.8	ns	-
16	17	5.0	21	4.0	ns	-

n = number of times the allele occurs; F = allele frequency; P-value = calculated by Fisher’s exact test; Pc-value = value of p corrected by Bonferroni correction; OR = odds ratio; 95%CI = 95% confidence interval; ns= not significant (p > 0.05).

ISSN: 1471-2334