Risk factors for pulmonary tuberculosis in patients with chronic obstructive airway disease in Taiwan: a nationwide cohort study

Table 6 Time-dependent Cox regression analysis for risk factors of pulmonary tuberculosis

Variables	Scenario 1		Scenario 2		Scenario 3
	pvalue	HR (95% CI)	pvalue	HR (95% CI)	pvalue	HR (95% CI)
Age (10 years)	<.0001	1.489 (1.436–1.545)	<.0001	1.385 (1.330–1.443)	<.0001	1.430 (1.363–1.501)
Male	<.0001	2.222 (1.929–2.559)	<.0001	2.145 (1.845–2.494)	<.0001	2.056 (1.741–2.427)
Diabetes mellitus	<.0001	1.456 (1.234–1.719)	<.0001	1.416 (1.189–1.687)	0.0163	1.256 (1.043–1.513)
Oral corticosteroids (g)	0.0004	1.171 (1.073–1.279)	0.0028	1.157 (1.051–1.273)	<.0001	1.185 (1.097–1.281)
Oral beta-agonists (30 DDD)	0.0007	1.056 (1.023–1.090)	0.0115	1.071 (1.015–1.130)	0.0029	1.051 (1.017–1.087)
Inhaled SAMA^* (30 DDD)	0.001	1.043 (1.017–1.069)	0.0053	1.039 (1.011–1.068)
Acute exacerbations	0.0008	1.026 (1.011–1.042)	0.0127	1.021 (1.004–1.038)
Low income					0.0027	1.8 (1.225–1.644)

HR: hazard ratio, CI: confidence interval, SAMA: short-acting muscarinic antagonists, DDD: defined daily dose
Time-dependent Cox regression analysis for the factors possibly associated with the development of active tuberculosis in cases of chronic obstructive pulmonary disease selected under scenarios 1–3.

ISSN: 1471-2334