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Table 4 Univariate analysis for risk factors for Day 14 and Day 30 mortalities, and unfavorable outcomes at end of teicoplanin therapy

From: Prognosis of patients with methicillin-resistant Staphylococcus aureusbloodstream infection treated with teicoplanin: a retrospective cohort study investigating effect of teicoplanin minimum inhibitory concentrations

Variables

Day 14 mortality

Day 30 mortality

Unfavorable outcome

 

OR

p value

OR

p value

OR

p value

Age

1.01

0.3749

1.02

0.0138

1.02

0.0628

Sex (male to female)

0.67

0.3025

0.84

0.5748

1.06

0.8281

Charlson comorbidity index

1.10

0.7972

2.73

0.0974

1.04

0.4988

Onset in ICU

1.08

0.8307

2.71

0.1147

1.44

0.1587

Presence of metastatic foci

1.79

0.1337

1.48

0.2079

1.21

0.5225

Endocarditis

0.95

0.9338

2.17

0.8592

2.16

0.0430

Septic shock

3.08

0.0083

18.11

<0.0001

8.44

<0.0001

Primary bacteremia

0.90

0.7724

0.69

0.1781

0.73

0.2215

Cardiovascular diseases

1.04

0.9336

1.63

0.1452

1.54

0.1503

Respiratory diseases

0.71

0.4507

1.01

0.9698

0.92

0.7860

Neurologic diseases

0.60

0.2247

0.79

0.4384

0.77

0.3388

Gastrointestinal tract diseases

0.42

0.0415

0.48

0.0157

0.90

0.6976

Hepatobiliary diseases

0.62

0.3419

0.56

0.1292

0.65

0.1934

Genitourinary tract diseases

0.98

0.9619

1.52

0.1338

1.31

0.2996

Endocrinologic diseases

1.07

0.8595

1.43

0.2029

1.47

0.1290

Malignancies

0.78

0.5217

0.94

0.8247

1.01

0.9860

Autoimmune diseases

4.27

0.0044

1.98

0.1543

0.72

0.5218

Immunosuppression

1.45

0.3246

1.39

0.2654

1.19

0.5264

Abnormal white blood cell count

      

  < 4,000/μL

1.26

0.6380

0.71

0.4259

0.79

0.5671

  > 12,000/μL

0.49

0.0851

0.59

0.0798

0.89

0.6658

Anemia

1.22

0.5959

1.11

0.7155

1.38

0.2135

Thrombocytopenia

4.20

0.0003

2.43

0.0017

1.35

0.2357

Hypoalbuminemia

3.40

0.2427

1.12

0.8368

2.09

0.1375

Abnormal liver function with clinical significance

6.94

0.0214

3.04

0.1815

1.85

0.4593

Abnormal renal function

1.34

0.4481

2.06

0.0168

1.58

0.0856

C-reactive protein

1.00

0.9269

1.00

0.9232

1.04

0.0166

Without effective treatment within 48 hours

0.77

0.5428

1.20

0.5698

0.87

0.6310

Adequate loading dose

0.932

0.8488

0.76

0.3335

0.93

0.7845

Combination therapy

1.46

0.3666

0.76

0.4481

0.60

0.1322

Teicoplanin MIC by broth dilution

0.76

0.5983

1.65

0.1712

1.02

0.9451

Teicoplanin MIC by Etest

0.90

0.7976

1.00

0.9949

1.15

0.6451

Sequence types (ST5, ST239 compared to other types)

  ST5

0.664

0.4758

0.61

0.2047

0.76

0.4346

  ST239

1.54

0.2992

0.85

0.6109

1.02

0.9531

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BMC Infectious Diseases

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