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Table 4 Diagnosis accuracy of serum PCT, CRP, WBC, body temperature, ΔCRP and ΔPCT for diagnosis of ICU-acquired infection

From: A composite score combining procalcitonin, C-reactive protein and temperature has a high positive predictive value for the diagnosis of intensive care-acquired infections

  AUC Cut-off level Sensitivity (%) Specificity (%) PPV NPV
PCT D0 0.84 1.86 ng/mL 68 91 68 91
CRP D0 0.88 88 mg/L 92 70 47 97
WBC D0 0.62 12120/mm3 64 68 36 87
Temperature D0 0.88 38.6°C 76 94 79 94
Composite score D0 0.90 28 80 97 87 94
ΔPCT 0.83 0.49 ng/mL 68 94 77 91
ΔCRP 0.85 12 mg/L 92 71 48 97
  1. Data are presented as % unless otherwise stated. AUC: area under the receiver-operating-characteristic curve; NPV: negative predictive value; PPV: positive predictive value.