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Table 1 Demographic, clinical data and primary outcome parameters

From: Procalcitonin-guided algorithm to reduce length of antibiotic therapy in patients with severe sepsis and septic shock

Year

2005

2006

2007

2008

2009

P §

p-value trend #

 

Patient (n)

38

31

27

27

18

   

Gender (m/f)

20/18

16/15

14/13

18/9

11/7

0.728

0.289

 

Age (years)*

68.6 ±15.9

73.8 ±9.5

68.0 ±13.5

67.5 ±13.9

65.4 ±11.6

0.196

0.125

 

SAPS II *

45.0 ±17.7

43.4 ±17.9

42.5 ±19.8

44.3 ±19.0

37.0 ±10.9

0.603

0.177

 

Apache II *

20.0 ±8.8

20.5 ±8.8

18.2 ±8.7

17.9 ±9.7

15.6 ±7.2

0.327

0.041

 

Effective cost weight *

14.8 ±13.6

13.3 ±11.4

17.2 ±14.0

14.5 ±13.6

19.2±18.5

0.623

0.256

 
 

Average change per year

Mean

95% CI

p

ICU stay (days)

26.0 ± 1.9

19.5 ± 2.2

18.5 ± 2.3

16.3 ± 2.3

15.8 ± 2.8

−2.7

−4.1 to −1.3

< 0.001

Ventilation (hours)

571.4 ± 41.5

455.0 ± 47.3

404.1 ± 49.2

362.0 ± 49.9

467.9 ± 60.9

−42.0

−72.6 to −11.4

0.008

Antibiotic use (days)

14.3 ± 1.2

12.0 ± 1.3

13.8 ± 1.4

12.1 ± 1.4

9.0 ± 1.7

−1.0

−1.9 to −0.2

0.02

Antibiotic costs (EUR/patient)

407.6 ± 57.2

420.7 ± 66.7

426.6 ± 67.7

393.2 ± 68.5

373.9 ± 83.7

−14.3

−55.7 to 27.1

0.495

ICU reinfection rate (proportion)

0.31 ± 0.07

0.37 ± 0.08

0.13 ± 0.06

0.12 ± 0.06

0.08 ± 0.06

−35.1%

−53.9% to −8.5%

0.014

28-day mortality (proportion)

0.54 ± 0.06

0.51 ± 0.07

0.55 ± 0.08

0.48 ± 0.07

0.34 ± 0.01

−22.4%

−44.3% to 8.1%

0.133

  1. Demographic and clinical data:
  2. * Mean ± standard deviation.
  3. § F test of ANOVA (continuous characteristic) or Wald chi square test (categorical characteristic) of logistic regression model.
  4. # Linear polynomial contrasts (continuous characteristic) or Cochran-Armitage trend tests (categorical characteristic).
  5. SAPS II, Simplified Acute Physiology Score II.
  6. APACHE II, Acute Physiology And Chronic Health Evaluation Score II.
  7. Primary outcome parameters:
  8. Adjusted Means ± standard error and average yearly change of outcome parameters, with 95 confidence limits (CI) and p values of trend tests from ANCOVA or logistic regression models with covariates gender, age, SAPS II, APACHE II and effective cost weight.