Table 4 The predicted and actual cure rates for CDI patients in the combined 003 and 004 trial databases (mITT patients who have available values for all analyzed variables), and also categorized by treatment assignment on entry into the studies (fidaxomicin or vancomycin)
| Â | All patients (n=967) | Vancomycin patients (n=494) | Fidaxomicin patients (n=473) | |||
|---|---|---|---|---|---|---|
ATLAS score | Predicted cure rate* (%) (nc/nT) | Actual cure rate (%) (nc/nT) | Predicted cure rate* (%) (nc/nT) | Actual cure rate (%) (nc/nT) | Predicted cure rate* (%) (nc/nT) | Actual cure rate (%) (nc/nT) |
0 | 100 (161/161) | 96.3 (155/161) | 100 (75/75) | 93.3 (70/75) | 100 (86/86) | 98.8 (85/86) |
1 | 94.9 (160/169) | 93.5 (158/169) | 94.9 (84/89) | 93.3 (83/89) | 94.9 (76/80) | 93.8 (75/80) |
2 | 89.8 (144/160) | 93.1 (149/160) | 89.8 (72/80) | 93.8 (75/80) | 89.8 (72/80) | 92.5 (74/80) |
3 | 84.8 (146/172) | 87.2 (150/172) | 84.8 (72/85) | 87.1 (74/85) | 84.8 (74/87) | 87.4 (76/87) |
4 | 79.7 (99/124) | 78.2 (97/124) | 79.7 (58/73) | 76.7 (56/73) | 79.7 (41/51) | 80.4 (41/51) |
5 | 74.6 (68/91) | 81.3 (74/91) | 74.6 (32/43) | 76.7 (33/43) | 74.6 (36/48) | 85.4 (41/48) |
6 | 69.5 (40/58) | 74.1 (43/58) | 69.5 (19/28) | 78.6 (22/28) | 69.5 (21/30) | 70 (21/30) |
7 | 64.4 (10/16) | 62.5 (10/16) | 64.4 (8/12) | 58.3 (7/12) | 64.4 (3/4) | 75 (3/4) |
8 | 59.4 (7/11) | 54.6 (6/11) | 59.4 (4/7) | 57.1 (4/7) | 59.4 (2/4) | 50 (2/4) |
9 | 54.3 (3/5) | 40 (2/5) | 54.3 (1/2) | 0 (0/2) | 54.3 (2/3) | 66.7 (2/3) |
10 | 49.2 (N/A) | N/A | 49.2 (N/A) | N/A | 49.2 (N/A) | N/A |
All scores | 86.7 (838/967) | 87.3 (844/967) | 86.0 (425/494) | 85.8 (424/494) | 87.3 (413/473) | 88.8 (420/473) |