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Table 2 Atypical Pap smear test results and association with specific HR-HPV types

From: Prevalence of high-risk HPV types and associated genital diseases in women born in 1988/89 or 1983/84 – results of WOLVES, a population-based epidemiological study in Wolfsburg, Germany

HR-HPV typea Prevalence of atypical Pap smear test results (%, 95% CIs) according to infection with specific HR-HPV types
1983/84 cohort (n = 659) 1988/89 cohort (n = 599)
HPV status ASC-US or more >LSIL CIN1+ HPV status ASC-US or more >LSIL CIN1+
HPV16 Negative 3.61 2.30 1.31 Negative 2.52 0.90 0.90
(n = 609) (2.28-5.42) (1.26-3.83) (0.57-2.57) (n = 555) (1.39-4.20) (0.29-2.09) (0.29-2.09)
Positive 22.00 16.00 14.00 Positive 9.09 2.27 4.55
(n = 50) (11.53-35.96) (7.17-29.11) (5.82-26.74) (n = 44) (2.53-21.67) (0.06-12.02) (0.56-15.47)
HPV18 Negative 4.50 2.95 2.02 Negative 2.75 1.03 1.03
(n = 645) (3.03-6.39) (1.78-4.56) (1.08-3.42) (n = 582) (1.58-4.43) (0.38-2.23) (0.38-2.23)
Positive 28.57 21.43 14.29 Positive 11.76 0 5.88
(n = 14) (8.39-58.10) (4.66-50.80) (1.78-42.81) (n = 17) (1.46-36.44) (0–19.51) (0.15-28.69)
HPV31 Negative 5.22 3.48 2.37 Negative 2.78 1.04 1.04
(n = 632) (3.62-7.26) (2.19-5.22) (1.33-3.88) (n = 575) (1.60-4.48) (0.38-2.26) (0.38-2.26)
Positive 0 0 0 Positive 8.33 0 4.17
(n = 27) (0–1.28) (0–1.28) (0–12.77) (n = 24) (1.03-27.00) (0–14.25) (0.11-21.12)
HPV33 Negative 5.05 3.36 2.29 Negative 3.03 1.01 1.18
n = 654) (3.50-7.01) (2.11-5.05) (1.29-3.75) (n = 594) (1.81-4.75) (0.37-2.19) (0.48-2.41)
Positive 0 0 0 Positive 0 0 0
(n = 5) (0–52.18) (0–52.18) (0–52.18) (n = 5) (0–52.18) (0–52.18) (0–52.18)
HPV35 Negative 4.88 3.35 2.13 Negative 3.02 1.01 1.17
(n = 656) (3.36-6.82) (2.11-5.03) (1.17-3.55) (n = 597) (1.80-4.72) (0.37-2.17) (0.47-2.40)
Positive 33.33 0 33.33 Positive 0 0 0
(n = 3) (0.84-90.57) (0–70.76) (0.84-90.57) (n = 2) (0–84.19) (0–84.19) (0–84.19)
HPV39 Negative 4.69 2.97 2.19 Negative 3.06 1.02 1.19
(n = 640) (3.18-6.62) (1.80-4.60) (1.20-3.64) (n = 589) (1.82-4.79) (0.37-2.20) (0.48-2.43)
Positive 15.79 15.79 5.26 Positive 0 0 0
(n = 19) (3.38-39.58) (3.38-39.58) (0.13-26.03) (n = 10) (0–30.85) (0–30.85) (0–30.85)
HPV51 Negative 4.49 2.72 1.76 Negative 2.58 0.55 1.10
(n = 624) (3.00-6.42) (1.59-4.33) (0.88-3.13) (n = 543) (1.42-4.29) (0.11-1.61) (0.41-2.39)
Positive 14.29 14.29 11.43 Positive 7.14 5.36 1.79
(n = 35) (4.81-30.26) (4.81-30.26) (3.20-26.74) (n = 56) (1.98-17.29) (1.12-14.87) (0..05-9.55)
HPV52 Negative 4.89 3.15 2.21 Negative 2.80 0.70 1.05
(n = 634) (3.35-6.87) (1.94-4.83) (1.21-3.68) (n = 572) (1.61-4.50) (0.19-1.78) (0.39-2.27)
Positive 8.00 8.00 4.00 Positive 7.41 7.41 3.70
(n = 25) (0.98-26.03) (0.98-26.03) (0.10-20.35) (n = 27) (0.91-24.29) (0.91-24.29) (0.09-18.97)
HPV53 Negative 4.43 2.85 2.06 Negative 2.78 0.87 1.22
(n = 632) (2.96-6.34) (1.70-4.46) (1.10-3.49) (n = 575) (1.60-4.48) (0.28-2.02) (0.49-2.49)
Positive 18.52 14.81 7.41 Positive 8.33 4.17 0
(n = 27) (6.30-38.08) (4.19-33.73) (0.91-24.29) (n = 24) (1.03-27.00) (0.11-21.12) (0–14.25)
HPV66 Negative 4.25 2.67 1.89 Negative 2.78 0.87 1.04
(n = 636) (2.82-6.12) (1.56-4.25) (0.98-3.27) (n = 575) (1.6-4.48) (0.28-2.02) (0.38-2.26)
Positive 26.09 21.74 13.04 Positive 8.33 4.17 4.17
(n = 23) (10.23-48.41) (7.46-43.70) (2.78-33.59) (n = 24) (1.03-27.00) (0.11-21.12) (0.11-21.12)
  1. aHPV subtypes were counted individually. In patients with multiple HR HPV infections, the data are reported for each subtype separately, e.g. a mixed HPV16/52 infection is included in the rows for both HPV16 and for HPV52.