Table 2 Atypical Pap smear test results and association with specific HR-HPV types
HR-HPV typea | Prevalence of atypical Pap smear test results (%, 95% CIs) according to infection with specific HR-HPV types | |||||||
|---|---|---|---|---|---|---|---|---|
1983/84 cohort (n = 659) | 1988/89 cohort (n = 599) | |||||||
HPV status | ASC-US or more | >LSIL | CIN1+ | HPV status | ASC-US or more | >LSIL | CIN1+ | |
HPV16 | Negative | 3.61 | 2.30 | 1.31 | Negative | 2.52 | 0.90 | 0.90 |
(n = 609) | (2.28-5.42) | (1.26-3.83) | (0.57-2.57) | (n = 555) | (1.39-4.20) | (0.29-2.09) | (0.29-2.09) | |
Positive | 22.00 | 16.00 | 14.00 | Positive | 9.09 | 2.27 | 4.55 | |
(n = 50) | (11.53-35.96) | (7.17-29.11) | (5.82-26.74) | (n = 44) | (2.53-21.67) | (0.06-12.02) | (0.56-15.47) | |
HPV18 | Negative | 4.50 | 2.95 | 2.02 | Negative | 2.75 | 1.03 | 1.03 |
(n = 645) | (3.03-6.39) | (1.78-4.56) | (1.08-3.42) | (n = 582) | (1.58-4.43) | (0.38-2.23) | (0.38-2.23) | |
Positive | 28.57 | 21.43 | 14.29 | Positive | 11.76 | 0 | 5.88 | |
(n = 14) | (8.39-58.10) | (4.66-50.80) | (1.78-42.81) | (n = 17) | (1.46-36.44) | (0–19.51) | (0.15-28.69) | |
HPV31 | Negative | 5.22 | 3.48 | 2.37 | Negative | 2.78 | 1.04 | 1.04 |
(n = 632) | (3.62-7.26) | (2.19-5.22) | (1.33-3.88) | (n = 575) | (1.60-4.48) | (0.38-2.26) | (0.38-2.26) | |
Positive | 0 | 0 | 0 | Positive | 8.33 | 0 | 4.17 | |
(n = 27) | (0–1.28) | (0–1.28) | (0–12.77) | (n = 24) | (1.03-27.00) | (0–14.25) | (0.11-21.12) | |
HPV33 | Negative | 5.05 | 3.36 | 2.29 | Negative | 3.03 | 1.01 | 1.18 |
n = 654) | (3.50-7.01) | (2.11-5.05) | (1.29-3.75) | (n = 594) | (1.81-4.75) | (0.37-2.19) | (0.48-2.41) | |
Positive | 0 | 0 | 0 | Positive | 0 | 0 | 0 | |
(n = 5) | (0–52.18) | (0–52.18) | (0–52.18) | (n = 5) | (0–52.18) | (0–52.18) | (0–52.18) | |
HPV35 | Negative | 4.88 | 3.35 | 2.13 | Negative | 3.02 | 1.01 | 1.17 |
(n = 656) | (3.36-6.82) | (2.11-5.03) | (1.17-3.55) | (n = 597) | (1.80-4.72) | (0.37-2.17) | (0.47-2.40) | |
Positive | 33.33 | 0 | 33.33 | Positive | 0 | 0 | 0 | |
(n = 3) | (0.84-90.57) | (0–70.76) | (0.84-90.57) | (n = 2) | (0–84.19) | (0–84.19) | (0–84.19) | |
HPV39 | Negative | 4.69 | 2.97 | 2.19 | Negative | 3.06 | 1.02 | 1.19 |
(n = 640) | (3.18-6.62) | (1.80-4.60) | (1.20-3.64) | (n = 589) | (1.82-4.79) | (0.37-2.20) | (0.48-2.43) | |
Positive | 15.79 | 15.79 | 5.26 | Positive | 0 | 0 | 0 | |
(n = 19) | (3.38-39.58) | (3.38-39.58) | (0.13-26.03) | (n = 10) | (0–30.85) | (0–30.85) | (0–30.85) | |
HPV51 | Negative | 4.49 | 2.72 | 1.76 | Negative | 2.58 | 0.55 | 1.10 |
(n = 624) | (3.00-6.42) | (1.59-4.33) | (0.88-3.13) | (n = 543) | (1.42-4.29) | (0.11-1.61) | (0.41-2.39) | |
Positive | 14.29 | 14.29 | 11.43 | Positive | 7.14 | 5.36 | 1.79 | |
(n = 35) | (4.81-30.26) | (4.81-30.26) | (3.20-26.74) | (n = 56) | (1.98-17.29) | (1.12-14.87) | (0..05-9.55) | |
HPV52 | Negative | 4.89 | 3.15 | 2.21 | Negative | 2.80 | 0.70 | 1.05 |
(n = 634) | (3.35-6.87) | (1.94-4.83) | (1.21-3.68) | (n = 572) | (1.61-4.50) | (0.19-1.78) | (0.39-2.27) | |
Positive | 8.00 | 8.00 | 4.00 | Positive | 7.41 | 7.41 | 3.70 | |
(n = 25) | (0.98-26.03) | (0.98-26.03) | (0.10-20.35) | (n = 27) | (0.91-24.29) | (0.91-24.29) | (0.09-18.97) | |
HPV53 | Negative | 4.43 | 2.85 | 2.06 | Negative | 2.78 | 0.87 | 1.22 |
(n = 632) | (2.96-6.34) | (1.70-4.46) | (1.10-3.49) | (n = 575) | (1.60-4.48) | (0.28-2.02) | (0.49-2.49) | |
Positive | 18.52 | 14.81 | 7.41 | Positive | 8.33 | 4.17 | 0 | |
(n = 27) | (6.30-38.08) | (4.19-33.73) | (0.91-24.29) | (n = 24) | (1.03-27.00) | (0.11-21.12) | (0–14.25) | |
HPV66 | Negative | 4.25 | 2.67 | 1.89 | Negative | 2.78 | 0.87 | 1.04 |
(n = 636) | (2.82-6.12) | (1.56-4.25) | (0.98-3.27) | (n = 575) | (1.6-4.48) | (0.28-2.02) | (0.38-2.26) | |
Positive | 26.09 | 21.74 | 13.04 | Positive | 8.33 | 4.17 | 4.17 | |
(n = 23) | (10.23-48.41) | (7.46-43.70) | (2.78-33.59) | (n = 24) | (1.03-27.00) | (0.11-21.12) | (0.11-21.12) | |