|
HR-HPV typea
|
Prevalence of atypical Pap smear test results (%, 95% CIs) according to infection with specific HR-HPV types
|
|---|
|
1983/84 cohort (n = 659)
|
1988/89 cohort (n = 599)
|
|---|
|
HPV status
|
ASC-US or more
|
>LSIL
|
CIN1+
|
HPV status
|
ASC-US or more
|
>LSIL
|
CIN1+
|
|---|
|
HPV16
|
Negative
|
3.61
|
2.30
|
1.31
|
Negative
|
2.52
|
0.90
|
0.90
|
|
(n = 609)
|
(2.28-5.42)
|
(1.26-3.83)
|
(0.57-2.57)
|
(n = 555)
|
(1.39-4.20)
|
(0.29-2.09)
|
(0.29-2.09)
|
|
Positive
|
22.00
|
16.00
|
14.00
|
Positive
|
9.09
|
2.27
|
4.55
|
|
(n = 50)
|
(11.53-35.96)
|
(7.17-29.11)
|
(5.82-26.74)
|
(n = 44)
|
(2.53-21.67)
|
(0.06-12.02)
|
(0.56-15.47)
|
|
HPV18
|
Negative
|
4.50
|
2.95
|
2.02
|
Negative
|
2.75
|
1.03
|
1.03
|
|
(n = 645)
|
(3.03-6.39)
|
(1.78-4.56)
|
(1.08-3.42)
|
(n = 582)
|
(1.58-4.43)
|
(0.38-2.23)
|
(0.38-2.23)
|
|
Positive
|
28.57
|
21.43
|
14.29
|
Positive
|
11.76
|
0
|
5.88
|
|
(n = 14)
|
(8.39-58.10)
|
(4.66-50.80)
|
(1.78-42.81)
|
(n = 17)
|
(1.46-36.44)
|
(0–19.51)
|
(0.15-28.69)
|
|
HPV31
|
Negative
|
5.22
|
3.48
|
2.37
|
Negative
|
2.78
|
1.04
|
1.04
|
|
(n = 632)
|
(3.62-7.26)
|
(2.19-5.22)
|
(1.33-3.88)
|
(n = 575)
|
(1.60-4.48)
|
(0.38-2.26)
|
(0.38-2.26)
|
|
Positive
|
0
|
0
|
0
|
Positive
|
8.33
|
0
|
4.17
|
|
(n = 27)
|
(0–1.28)
|
(0–1.28)
|
(0–12.77)
|
(n = 24)
|
(1.03-27.00)
|
(0–14.25)
|
(0.11-21.12)
|
|
HPV33
|
Negative
|
5.05
|
3.36
|
2.29
|
Negative
|
3.03
|
1.01
|
1.18
|
|
n = 654)
|
(3.50-7.01)
|
(2.11-5.05)
|
(1.29-3.75)
|
(n = 594)
|
(1.81-4.75)
|
(0.37-2.19)
|
(0.48-2.41)
|
|
Positive
|
0
|
0
|
0
|
Positive
|
0
|
0
|
0
|
|
(n = 5)
|
(0–52.18)
|
(0–52.18)
|
(0–52.18)
|
(n = 5)
|
(0–52.18)
|
(0–52.18)
|
(0–52.18)
|
|
HPV35
|
Negative
|
4.88
|
3.35
|
2.13
|
Negative
|
3.02
|
1.01
|
1.17
|
|
(n = 656)
|
(3.36-6.82)
|
(2.11-5.03)
|
(1.17-3.55)
|
(n = 597)
|
(1.80-4.72)
|
(0.37-2.17)
|
(0.47-2.40)
|
|
Positive
|
33.33
|
0
|
33.33
|
Positive
|
0
|
0
|
0
|
|
(n = 3)
|
(0.84-90.57)
|
(0–70.76)
|
(0.84-90.57)
|
(n = 2)
|
(0–84.19)
|
(0–84.19)
|
(0–84.19)
|
|
HPV39
|
Negative
|
4.69
|
2.97
|
2.19
|
Negative
|
3.06
|
1.02
|
1.19
|
|
(n = 640)
|
(3.18-6.62)
|
(1.80-4.60)
|
(1.20-3.64)
|
(n = 589)
|
(1.82-4.79)
|
(0.37-2.20)
|
(0.48-2.43)
|
|
Positive
|
15.79
|
15.79
|
5.26
|
Positive
|
0
|
0
|
0
|
|
(n = 19)
|
(3.38-39.58)
|
(3.38-39.58)
|
(0.13-26.03)
|
(n = 10)
|
(0–30.85)
|
(0–30.85)
|
(0–30.85)
|
|
HPV51
|
Negative
|
4.49
|
2.72
|
1.76
|
Negative
|
2.58
|
0.55
|
1.10
|
|
(n = 624)
|
(3.00-6.42)
|
(1.59-4.33)
|
(0.88-3.13)
|
(n = 543)
|
(1.42-4.29)
|
(0.11-1.61)
|
(0.41-2.39)
|
|
Positive
|
14.29
|
14.29
|
11.43
|
Positive
|
7.14
|
5.36
|
1.79
|
|
(n = 35)
|
(4.81-30.26)
|
(4.81-30.26)
|
(3.20-26.74)
|
(n = 56)
|
(1.98-17.29)
|
(1.12-14.87)
|
(0..05-9.55)
|
|
HPV52
|
Negative
|
4.89
|
3.15
|
2.21
|
Negative
|
2.80
|
0.70
|
1.05
|
|
(n = 634)
|
(3.35-6.87)
|
(1.94-4.83)
|
(1.21-3.68)
|
(n = 572)
|
(1.61-4.50)
|
(0.19-1.78)
|
(0.39-2.27)
|
|
Positive
|
8.00
|
8.00
|
4.00
|
Positive
|
7.41
|
7.41
|
3.70
|
|
(n = 25)
|
(0.98-26.03)
|
(0.98-26.03)
|
(0.10-20.35)
|
(n = 27)
|
(0.91-24.29)
|
(0.91-24.29)
|
(0.09-18.97)
|
|
HPV53
|
Negative
|
4.43
|
2.85
|
2.06
|
Negative
|
2.78
|
0.87
|
1.22
|
|
(n = 632)
|
(2.96-6.34)
|
(1.70-4.46)
|
(1.10-3.49)
|
(n = 575)
|
(1.60-4.48)
|
(0.28-2.02)
|
(0.49-2.49)
|
|
Positive
|
18.52
|
14.81
|
7.41
|
Positive
|
8.33
|
4.17
|
0
|
|
(n = 27)
|
(6.30-38.08)
|
(4.19-33.73)
|
(0.91-24.29)
|
(n = 24)
|
(1.03-27.00)
|
(0.11-21.12)
|
(0–14.25)
|
|
HPV66
|
Negative
|
4.25
|
2.67
|
1.89
|
Negative
|
2.78
|
0.87
|
1.04
|
|
(n = 636)
|
(2.82-6.12)
|
(1.56-4.25)
|
(0.98-3.27)
|
(n = 575)
|
(1.6-4.48)
|
(0.28-2.02)
|
(0.38-2.26)
|
|
Positive
|
26.09
|
21.74
|
13.04
|
Positive
|
8.33
|
4.17
|
4.17
|
|
(n = 23)
|
(10.23-48.41)
|
(7.46-43.70)
|
(2.78-33.59)
|
(n = 24)
|
(1.03-27.00)
|
(0.11-21.12)
|
(0.11-21.12)
|
-
aHPV subtypes were counted individually. In patients with multiple HR HPV infections, the data are reported for each subtype separately, e.g. a mixed HPV16/52 infection is included in the rows for both HPV16 and for HPV52.
