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Table 2 The Xpert MTB/RIF test evaluation among children with suspected pulmonary TB (N = 235)

From: Evaluation of the Xpert MTB/RIF test for the diagnosis of childhood pulmonary tuberculosis in Uganda: a cross-sectional diagnostic study

  Overall (n = 235) HIV positive (n = 99) HIV negative (n = 136)
  Estimate 95% CI Estimate 95% CI Estimate 95% CI
Sensitivity (%) 27/34, 79.4 63.2 - 89.7 9/11,81.8 52.3-94.9 18/23, 78.3 58.1-90.3
Specificity (%) 194/201, 96.5 93- 98.3 84/88,95.5 88.9- 98.2 110/113, 97.4 92.5- 99.1
PPV (%) 79.4 63.2- 89.7 69.2 42.4- 87.3 85.7 65.4- 95
NPV (%) 96.2 93-98.3 97.7 91.9-99.4 95.7 90.2- 98.1
Diagnostic accuracy (%) 94 90.3- 96.4 93.9 87.4-97.2 94.1 88.8- 97
Likelihood ratio (+) 22.8 16.9 - 30.7 18 10.5 - 30.8 29.5 14.9- 58.4
Likelihood ratio (-) 0.2 0.2- 0.3 0.2 0.1-0.5 0.2 0.2 - 0.3
  1. PPV – Positive Predictive Value; NPV – Negative Predictive Value.