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Table 1 Demographic characteristics of the study subjects, drug resistance patterns, phylogenetic lineages and their association with strain clustering

From: Molecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in Northwest Ethiopia: new phylogenetic lineages found in Northwest Ethiopia

Characteristics Genotyping patterns OR (95% CI) p-value
  Clustered Unique   
Gender     
Male 63 79 0.9 (0.6-1.6) 0.791
Female 47 55 1  
Age group ( years )     
≤ 45 93 117 0.8 (0.4-1.6) 0.534
>45 17 17 1  
Address     
Rural 52 60 1.1 (0.7-1.8) 0.697
Urban 58 74 1  
Religion     
Christian 108 130 1.7(0.3-9.2) 0.693*
Muslim 2 4 1  
Previous TB treatment     
Yes 26 17 2.1(1.1-4.2) 0.026
No 84 117 1  
HIV status     
Positive 24 38 0.7 (0.4-1.3) 0.243
Negative 86 96 1  
Isoniazid     
Resistant 22 12 2.5 (1.2-5.4) 0.013
Sensitive 88 122 1  
Rifampicin     
Resistant 9 5 2.3 (0.7-7.1) 0.137
Sensitive 101 129 1  
Streptomycin     
Resistant 19 7 3.8(1.5-9.4) 0.002
Sensitive 91 127 1  
Ethambutol     
Resistant 14 4 4.7 (1.5-14.9) 0.004
Sensitive 96 130 1  
Pyrazinamid     
Resistant 8 4 2.5(0.7-8.7) 0.123
Sensitive 102 130 1  
Resistant to one or more FLD     
Resistant 25 15 2.3(1.2-4.7) 0.015
Sensitive 85 119 1  
MDR-TB     
Yes 8 4 2.5(0.7-8.7) 0.123
No 102 130 1  
Resistant to all FLD     
Yes 8 1 10.4 (1.3-84.7) 0.012*
No 102 133 1  
M. tuberculosis lineages     
Dehli/CAS 51 44 6.2 (1.7-22.6) 0.006
Ethiopia_3 23 9 13.6(3.2-58.3) <0.001
Haarlem 9 12 4.0(0.9-18.0) 0.071
Ethiopia_1§ 3 16 1 -
Ethiopia_H37Rv like 9 8 6.0 (1.3-28.5) 0.024
Ethiopia_2 4 5 4.3 (0.7-25.9) 0.115
URAL 0 8 - -
LAM 3 5 3.2(0.5-21.2) 0.228
TUR 4 1 21.3(1.7- 263.7) 0.017
X-type 0 3 - -
S-type 0 2 - -
Beijing 0 1 - -
UgandII 0 1 - -
Not defined 4 19 1.1(0.2-5.8) 0.890
Total 110 (45.1) 134 (54.9) - -
  1. *=Fisher exact test, FLD= First line anti-TB drugs, MDR= Multidrug resistant, §= reference category, LAM= M. tuberculosis Latin American Mediterranean.