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Table 1 Demographic characteristics of the study subjects, drug resistance patterns, phylogenetic lineages and their association with strain clustering

From: Molecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in Northwest Ethiopia: new phylogenetic lineages found in Northwest Ethiopia

Characteristics

Genotyping patterns

OR (95% CI)

p-value

 

Clustered

Unique

  

Gender

    

Male

63

79

0.9 (0.6-1.6)

0.791

Female

47

55

1

 

Age group ( years )

    

≤ 45

93

117

0.8 (0.4-1.6)

0.534

>45

17

17

1

 

Address

    

Rural

52

60

1.1 (0.7-1.8)

0.697

Urban

58

74

1

 

Religion

    

Christian

108

130

1.7(0.3-9.2)

0.693*

Muslim

2

4

1

 

Previous TB treatment

    

Yes

26

17

2.1(1.1-4.2)

0.026

No

84

117

1

 

HIV status

    

Positive

24

38

0.7 (0.4-1.3)

0.243

Negative

86

96

1

 

Isoniazid

    

Resistant

22

12

2.5 (1.2-5.4)

0.013

Sensitive

88

122

1

 

Rifampicin

    

Resistant

9

5

2.3 (0.7-7.1)

0.137

Sensitive

101

129

1

 

Streptomycin

    

Resistant

19

7

3.8(1.5-9.4)

0.002

Sensitive

91

127

1

 

Ethambutol

    

Resistant

14

4

4.7 (1.5-14.9)

0.004

Sensitive

96

130

1

 

Pyrazinamid

    

Resistant

8

4

2.5(0.7-8.7)

0.123

Sensitive

102

130

1

 

Resistant to one or more FLD

    

Resistant

25

15

2.3(1.2-4.7)

0.015

Sensitive

85

119

1

 

MDR-TB

    

Yes

8

4

2.5(0.7-8.7)

0.123

No

102

130

1

 

Resistant to all FLD

    

Yes

8

1

10.4 (1.3-84.7)

0.012*

No

102

133

1

 

M. tuberculosis lineages

    

Dehli/CAS

51

44

6.2 (1.7-22.6)

0.006

Ethiopia_3

23

9

13.6(3.2-58.3)

<0.001

Haarlem

9

12

4.0(0.9-18.0)

0.071

Ethiopia_1§

3

16

1

-

Ethiopia_H37Rv like

9

8

6.0 (1.3-28.5)

0.024

Ethiopia_2

4

5

4.3 (0.7-25.9)

0.115

URAL

0

8

-

-

LAM

3

5

3.2(0.5-21.2)

0.228

TUR

4

1

21.3(1.7- 263.7)

0.017

X-type

0

3

-

-

S-type

0

2

-

-

Beijing

0

1

-

-

UgandII

0

1

-

-

Not defined

4

19

1.1(0.2-5.8)

0.890

Total

110 (45.1)

134 (54.9)

-

-

  1. *=Fisher exact test, FLD= First line anti-TB drugs, MDR= Multidrug resistant, §= reference category, LAM= M. tuberculosis Latin American Mediterranean.