Nosocomial outbreak of the pandemic Influenza A (H1N1) 2009 in critical hematologic patients during seasonal influenza 2010-2011: detection of oseltamivir resistant variant viruses

Table 1 Clinical Characteristic of six patients with/or without Oseltamivir resistant influenza A (H1N1) virus infection

	Patient 1 Index case	Patient 2	Patient 3 Ψ	Patient 4	Patient 5 Ψ	Patient 6 Ψ
Sex	Female	Male	Male	Male	Male	Male
Age	76	50	39	42	65	24
Medical history	Non Hodgkin Lymphoma	Diffuse large cell Lymphoma	Non Hodgkin Lymphoma, HIV+ patient	Acute Myeloid Leukemia	Multiple myeloma, allogenic stem cell transplantation	Acute lymphoblastic leukemia
Respiratory symptoms	Fever and cough	Fever, Dyspnea, oxygen dependent	Fever, Dyspnea, oxygen dependent	Fever and cough	Fever, Dyspnea, oxygen dependent	Fever, Dyspnea, oxygen dependent
Confirmed diagnosis	Flu lower respiratory tract infection	Pneumonia	Pneumonia	Flu lower respiratory tract infection	Pneumonia	Pneumonia
First positive test result for Flu A	January 26	January 31	January 31	February 1	February 2	February 14
Antiviral theraphy	Oseltamir	Oseltamir	Oseltamir	Oseltamir	Oseltamir	Oseltamir
Oseltamivir resistance	No	Yes	No	Yes	Yes	No
Chest X-ray	No pulmonary abnormalities	Left lower-lobe consolidation	Bilateral lower lobe consolidations	No Pulmonary abnormalities	Perihilar consolidations	Bilateral lower lobe consolidations
Flu A outcome	Viral clearance	Viral clearance	Fatal influenza pneumonia	Viral clearance	Fatal influenza pneumonia	Fatal influenza pnemonia

ISSN: 1471-2334