Rv0447c
|
NP854118 (Pool 1)
|
Probable cyclopropane fatty acyl phospholipid synthase.
|
427
|
Methyl transferase activity. Cyclopropane fatty acyl phospholipid synthase activity. Lipid biosynthetic process [17, 18]
|
Rv2940c
|
YP_976584 (Pool 2)
|
Mycocerosic acid synthase
|
2111
|
Lipid biosynthetic process. Oxido-reduction and transferase activity, Cofactor binding. Location at the cell wall. [17, 19–23]
|
Rv3347c
|
YP_177963 (Pool 3)
|
PPE family protein
|
3157
|
Function unknown. Gly-Ala-Asn rich protein, interacts with the host system by inhibition of antigen processing. [18, 23–26]
|
Rv2453c
|
CAA16030 (Pool 4)
|
Probable molybdopterin-guanine dinucleotide biosynthesis Protein A
|
201
|
Molybdenum cofactor biosynthesis. Molecular function as GTP binding. Located at the cytoplasm membrane. [18, 23, 24, 27]
|
Rv1886c
|
CAB10044 (Pool 5)
|
Antigen 85B
|
325
|
Fibronectin binding protein. Acyltransferase activity. Secreted protein, also located at cell wall, plasma membrane. [18, 28–31]
|
Rv1690
|
CAB10947 (Pool 6)
|
Probable lipoprotein
|
127
|
Putative uncharacterized protein. Protein binding, cellular component plasma membrane.[18, 24, 32]
|
Rv3019c
|
CAA16104 (Pool 7)
|
ESAT-6 like protein
|
96
|
Belongs to ESAT-6 (esx) family, Protein-protein interaction [18, 24]
|
Rv2957
|
CAB05419 (Pool 8)
|
PGL/p-HBAD biosynthesis glycosyltrans-ferase MT3031
|
256
|
Glycosyl transferase activity, transferring hexosyl groups. Glycolipid biosynthetic function. Identified as a drug target. [18, 24, 30, 33, 34]
|
Rv1085c
|
CAA17201 (Pool 9)
|
UPF0073 membrane protein
|
242
|
Belongs to the UPF0073 (HIy-III) family. Cytolysis. Sub cellular location in cell membrane [18, 24]
|
Rv0066c
|
CAA16247 (Pool 10)
|
Isocitrate dehydrogenase, NADP-dependent- icd2.
|
745
|
Oxidoreductase function. NAD or NADH binding. Isocitrate dehidrogenase (NADP+) activity. Magnesium ion binding. Protein homodimerization. [18, 22–24, 35, 36]
|
Rv2958c
|
CAB05418 (Pool 11)
|
PGL/p-HBAD biosynthesis glycosyltrans-ferase
|
428
|
Glycolipid biosynthetic process, pathogenesis, Glycosyl transferase activity. Immune evasion or - tolerance [18, 22, 24, 33, 37]
|
Rv2962c
|
CAB05415 (Pool 12)
|
PGL/p-HBAD biosynthesis rhamnosyl-transferase
|
449
|
Glycolipid biosynthetic process, pathogenesis. Glycosyl transferase activity. Evasion or tolerance concerning to the host immune response. [18, 22, 24, 30, 33, 37]
|
Rv3804c/1886
|
CAA17868/CAB10044
|
Ag85A/Ag85B Fibronecting binding protein peptide pool
|
338/325
|
Belongs to the Ag85 family, contains Esterase D. Possesses mycolyl transferase activity. [28, 29, 38–41]
|
Proteins
| | | | |
Rv3804c
|
CAA17868
|
Ag85A. Secreted antigen 85A. Mycolyl transferase 85A. fbpA. Ag85 complex
|
338
|
Responsible for high affinity of mycobacteria to fibronectin. Possesses mycolyl transferase for biogenesis of trehalose dimycolate. [22, 23, 29, 30, 38–40, 42–44]
|
Rv1886c
|
CAB10044
|
Ag85B. Secreted antigen 85B. Mycolyl transferase 85B. fbpB. Ag85 complex
|
325
|
Fibronectin binding protein. Acyltransferase activity. Response to antibiotic. Secreted protein also located at cell wall, extracellular region. [28–30, 36, 38, 40, 41, 45]
|
Rv3875
|
CAA56099
|
ESAT-6. 6 KDa early secretory antigenic target. esxA
|
95
|
Function unknown. Elicit high level of IFNgamma during the first phase of protective immune response. Secreted protein, cell wall and cytoplasm. [46–54]
|
Rv3874
|
CAA17966
|
CFP-10. 10 KDa culture filtrate antigen
|
100
|
ESAT-6 like protein esxB. Forms a tight 1:1 complex with EsxA. Protein binding. Host cell surface binding. Pathogenesis. Protein secretion. [22, 47–49, 51, 53, 54]
|
Rv0754
|
CAE55319
|
PE_PGR11. PE-PGRS family protein
|
584
|
Member of M.tb PE family. PGRS subfamily gly-rich proteins. Unknown function. Protein existence predicted. [18, 21]
|
Rv0978c
|
CAE55343
|
PE_PGR17. PE-PGRS family protein
|
331
|
Member of M.tb PE family. PGRS subfamily gly-rich proteins. Unknown function. Protein existence predicted. [18, 55, 56]
|
Rv1917c
|
CAE55440
|
PPE34. PPE family protein
|
1459
|
Member of M.tb PPE family. Glycin rich proteins. Unknown function. [18, 57]
|
Rv0288
|
CAA17363
|
TB10.4. Low molecular weight protein. (M.tb)
|
96
|
Belongs to theESAT-6 (esx) family. Molecular function protein binding. Involved in virulence. Immunogenic. [18, 24, 58–61]
|