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Table 4 Plasma cytokine concentrations in children with different disease severity

From: Endotoxaemia is common in children with Plasmodium falciparummalaria

 

Non-severe malaria

Severe malaria

Severe malaria & shock

Fatal cases

Pa

N

44

30

126

10

 

TNFα (pg/ml) b

0 (0–19.3)

0 (0–59.3)

28.8 (0–70)

0 (0–115)

0.014

IL6 (pg/ml) b

0 (0–20.8)

0 (0–82)

52.5 (0–219)

524 (30–1252)

<0.0001

IL10 (pg/ml) b

105 (0–373)

211 (59–744)

471 (135–1159)

492 (62–1924)

0.002

TGFβ (pg/ml) b

467 (83–1371)

453 (0–938)

510 (0–1101)

793 (0–1037)

0.499

I-FABP (pg/ml) b,c

0 (0–205)

0 (0–429)

0 (0–310)

218 (0–1138)

0.217

  1. aKruskal Wallis H test.
  2. bShown are median and 25th and 75th percentile.
  3. cThe plasma concentration of I-FABP was measured in 43 children with non-severe malaria, 30 children with severe malaria, 116 children with severe malarial shock and 9 fatal cases.