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Table 4 Plasma cytokine concentrations in children with different disease severity

From: Endotoxaemia is common in children with Plasmodium falciparummalaria

  Non-severe malaria Severe malaria Severe malaria & shock Fatal cases Pa
N 44 30 126 10  
TNFα (pg/ml) b 0 (0–19.3) 0 (0–59.3) 28.8 (0–70) 0 (0–115) 0.014
IL6 (pg/ml) b 0 (0–20.8) 0 (0–82) 52.5 (0–219) 524 (30–1252) <0.0001
IL10 (pg/ml) b 105 (0–373) 211 (59–744) 471 (135–1159) 492 (62–1924) 0.002
TGFβ (pg/ml) b 467 (83–1371) 453 (0–938) 510 (0–1101) 793 (0–1037) 0.499
I-FABP (pg/ml) b,c 0 (0–205) 0 (0–429) 0 (0–310) 218 (0–1138) 0.217
  1. aKruskal Wallis H test.
  2. bShown are median and 25th and 75th percentile.
  3. cThe plasma concentration of I-FABP was measured in 43 children with non-severe malaria, 30 children with severe malaria, 116 children with severe malarial shock and 9 fatal cases.