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Table 2 Spectrum of clinical presentations of severe malaria in children in Kilifi, Kenya and Mbale, Uganda

From: Endotoxaemia is common in children with Plasmodium falciparummalaria

  KDH MRRH P
Age (months) a 48.5 (37.6-70.7) 24 (13.1-42.3) <0.0001
Impaired perfusion b 79.2% (38/48) 73.2% (115/157) 0.410
Respiratory distress b 45.8% (22/48) 91.1% (143/157) <0.0001
Impaired consciousness b 91.7% (44/48) 54.1% (85/157) <0.0001
Coma b 31.3% (15/48) 14% (22/157) 0.007
Severe anaemia b 14.6% (7/48) 32.9% (50/152) 0.014
Mortality (48 h) b 4.2% (2/48) 5.1% (8/157) 0.794
Endotoxaemia b 12.5% (6/48) 31.2% (49/157) 0.01
High endotoxaemia b 2.1% (1/48) 11.5% (18/157) 0.05
  1. a Shown are median and in parenthesis 25th and 75th percentile. For comparison of difference in age between groups, Kruskal-Wallis H test was used.
  2. b Percentage of children presenting with syndrome and in parenthesis the number of children presenting with a syndrome over the total number of children in that group. For comparison of the proportion of children presenting with a given syndrome, Pearson χ2 was used. Differences in mortality were not calculated because all cases occurred in the group of children with severe malaria and shock.