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Table 2 Summary of the number and rates of children with candidias per 1,000 children with hospital admission/year (bold font) and specific candidiasis diagnoses per 1,000 children with hospital admission/year (non-bold font) in HIV-infected children and HIV-uninfected children in Spain from 1997 to 2008

From: Rate of candidiasis among HIV-infected children in Spain in the era of highly active antiretroviral therapy (1997–2008)

  

HIV-uninfected children

HIV-infected children

Description

ICD-9 codex

No.

Rate (95% CI)

No.

Rate (95% CI)

All candidiasis

112.XX

26

5.0 (3.1; 6.9)

141

107.0 (90.1; 125.7) (*)

Non-invasive Candida mycosis (Non-ICM)

 

16

3.1 (1.6; 4.6)

120

91.8 (75.4; 108.3) (*, †)

   Candidiasis of mouth

112.0

13

2.5 (1.1; 3.8)

104

79.6 (64.6; 94.7) (*)

   Candidiasis of vulva and vagina

112.1

0

-

2

1.5 (0; 3.6)

   Candidiasis of other urogenital sites

112.2

0

-

4

3.1 (0.1; 6.1)

   Candidiasis of skin and nails

112.3

3

0.6 (0; 1.2)

5

3.8 (0.5; 7.2) (*)

   Candidal otitis external

112.82

0

-

1

0.7 (0; 2.3)

   Candidal esophagitis

112.84

0

-

12

9.2 (4.0; 14.4)

Invasive Candida mycosis (ICM)

 

10

1.9 (0.7, 3.1)

21

16.1 (9.2; 23.0) (*)

   Disseminated candidiasis

112.5

1

0.2 (0; 0.6)

3

2.3 (0; 4.9) (*)

   Candidal enteritis

112.85

0

-

5

3.8 (0.5; 7.2)

   Other candidiasis of other specified sites

112.89

6

1.1 (0.2; 2.1)

7

5.3 (1.4; 9.3) (*)

   Candidiasis of unspecified site

112.9

1

0.2 (0; 0. 6)

4

3.1 (0.1; 6.1) (*)

   Neonatal candida infection

771.7

2

0.4 (0; 0.9)

2

1.5 (0; 3.6)

  1. Abbreviations: ICM, invasive candidiasis mycosis; HIV, Human immunodeficiency virus; ICD-9, data are coded according to the International Classification of Diseases (9th revision, Clinical Modification [ICD-9-MC]); Rate, events per 1,000 children with hospital admission/year; 95% CI, 95% of confidence interval.
  2. (†): Significant differences between groups of study within a candidiasis diagnosis category (p < 0.001).
  3. (*): Significant differences between Non-ICM and ICM categories within a study group (p < 0.001).