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Table 2 Voriconazole dosing characteristics, drug level monitoring, and duration of therapy

From: Voriconazole therapeutic drug monitoring: retrospective cohort study of the relationship to clinical outcomes and adverse events

Voriconazole therapy

Median value[(IQR]

Voriconazole serial drug levels (mg/L)

 

Initial drug level (n = 108)

2.35 [0.7, 3.8]

Second drug level (n = 51)

2.00 [0.5, 3.5]

Third drug level (n = 26)

1.35 [0.6, 7.7]

Voriconazole loading dose (mg/dose; n = 59)

400 [350, 480]

Voriconazole maintenance dose (mg/dose; n = 107)

260 [200,300]

Patient weight (kg; n = 107)

71.3 [60.5, 85.8]

Duration of voriconazole therapy in days (n = 85)

35 [13, 92]

Days between initiation of voriconazole to first drug level (n = 100)

11 [3,164]

Hours between last dose and trough drug level (n = 64)

11.3 [8.9-12.0]