Comparison of activation levels in CD4
subsets between HIV
and HIV- donors. PBMC samples from 19 HIV+ and 10 HIV- donors were characterized by flow cytometry. The CD3+CD4+CD45RA+ and CD3+CD4+CD45RA- populations were assessed for expression of both CD38 and HLA-DR. Activation levels of the CD4+ subsets from HIV+ donors (open symbols), and HIV- donors (filled symbols) are shown. Box and whisker plots (in grey) extend from the 5th to the 95th percentile, and the black line depicts the mean. Unpaired 2-tailed t-tests were conducted to compare activation levels between HIV+ and HIV- populations, and Mann–Whitney tests used to compare levels within HIV+ or HIV- populations.