|  |  |  | Crowding Variables |  | |
---|---|---|---|---|---|---|
Reference | Study Type/Population | Numberof Participants | Age Criteria | ≥1 Significant in Unadjusted Analysis | ≥1 Significant in Adjusted Analysis | Bias Assessment b |
High-risk population, (n = 9) |  |  |  |  | ||
Broughton et al., 2005 c[15] | Cohor, <32-week GA, UK | N = 126 | ≤1 year | Not conducted | Yes | No apparent bias concerns |
Bulkow et al., 2002[23] | Case–control, Alaska natives, US | Cases n = 204 Controls n = 338 | <3 years | Yes | Yes | No apparent bias concerns |
Carbonell-Estrany et al., 2000[24] | Cohort, ≤32-week GA, Spain | N = 584 | ≤1 year | Yes | Yes | No apparent bias concerns |
Carbonell-Estrany et al., 2001[25] | Cohort, ≤32-week GA, Spain | N = 999 | ≤6 months in October | Yes | Yes | No apparent bias concerns |
Figueras-Aloy et al., 2004[26] | Case–control, 33- to 35-week GA, Spain | Cases n = 186 Controls n = 371 | <1 year | Yes | Yes | No apparent bias concerns |
Figueras-Aloy et al., 2008[18] | 2 Cohorts, 32- to 35-week GA, Spain | Cohort 1 (cases), n = 202 Cohort 2 (controls), n = 5239 | Discharged during or ≤6 months of age at start of RSV season | Yes | Not applicabled | No apparent bias concerns |
Kanra et al., 2005[27] | Cohort, 64.3% preterm (<35-week GA), 20.8% CHF, Turkey | N = 332 | <6 months and preterm; <2 years with CLD | No | Not conducted | No multivariate analysis |
Law et al., 2004[19] | Cohort, 33- to 35-week GA, Canada | N = 1860 | ≤7 months (or older to end of RSV season) | Yes | Yes | No apparent bias concerns |
Simoes et al., 1993[22] | Case–control, Multiples vs. singletons, all ≤32-week GA with CLD; US | Cases n = 34 Controls n = 34 Combined group analyzed | <2 years | Yes | NR | Multivariate analysis NR |
Mixed-risk population, (n = 11) |  |  |  |  | ||
Albargish and Hasony, 1999 c[16] | Cross-sectional study, Iraq | n = 500 with LRTI (37.6% RSV-positive); n = 57 controls | <5 years | No | Not conducted | No multivariate analysis |
Flores et al., 2004 c[14] | Cohort, Portugal | N = 225 (137 RSV-positive, 88 RSV-negative) | <3 years | No | Not conducted | No multivariate analysis |
Hayes et al., 1989[21] | Case–control, American Samoa | Cases n = 13 Controls n = 45 | <2 years | Yes | Not conducted | No multivariate analysis |
Holberg et al., 1991 c[17] | Cohort, US | N = 1179 | ≤1 year | Yes | Yes | No apparent bias concerns |
Lanari et al., 2002[28] | Cohort, Italy | N = 1232 | <2 years | Yes | Not conducted | No multivariate analysis |
Nielsen et al., 2003[20] | Case–control, Denmark | Cases n = 1272 Controls n = 6075 | <2 years | Not conducted | Yes | No apparent bias concerns |
Okiro et al., 2008 c[9] | Cohort, Kenya | N = 469 | <2 weeks old, followed for 3 RSV seasons | Yes | Yes | No apparent bias concerns |
Reeve et al., 2006[29] | Case–control, Australia | Cases n = 271 Controls n = 542 | <3 years | Not conducted | Yes | No apparent bias concerns |
Rossi et al., 2007[30] | Case–control, Italy | Cases n = 145 Controls n = 292 | ≤4 years | Yes | Yes | No apparent bias concerns |
von Linstow et al., 2008[31] | Cohort, Denmark | N = 217 | ≤1 year | Yes | Yes | No apparent bias concerns |
Weber et al., 1999[32] | Case–control, Gambia | Cases n = 277 Controls n = 364 | Not specified, median 9 months | Yes | Yes | No apparent bias concerns |