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Table 3 Frequency distribution of mutations across rpoB, katG and inhA genes

From: Drug resistance mutations and heteroresistance detected using the GenoType MTBDRplusassay and their implication for treatment outcomes in patients from Mumbai, India

Pattern

rpoB

katG

inhA

n (onset)

n (5th month)

Only INH (n = 22)

-

-

A16G mixed

6

1

 

-

S315T1

-

3

1

 

-

-

ΔWT2

2

0

 

-

-

C15T

2

0

 

-

S315T1, T2

-

2

0

 

-

S315T1, T2 mixed

-

2

0

 

-

S315T1, T2

A16G mixed

1

0

 

-

S315T1 mixed

-

1

0

 

-

S315T1, T2 mixed

A16G mixed

1

0

Only RIF

(n = 4)

Δ WT8

-

-

1

1

 

ΔWT6, 7, 8

-

-

0

1

 

D516V mixed

-

-

1

0

MDR

(n = 82)

ΔWT8

S315T1, T2 mixed

-

2

11

 

D516V mixed

-

A16G mixed

4

5

 

ΔWT8

-

ΔWT2

1

6

 

ΔWT8

-

A16G mixed

3

4

 

S531L

S315T1

-

1

4

 

D516V mixed, ΔWT8

-

A16G mixed

0

4

 

S531L

S315T1, T2 mixed

-

1

3

 

D516V mixed, S531L

S315T1, S315T2

-

0

3

 

ΔWT8

S315T2 mixed

-

1

1

 

ΔWT7, 8

-

ΔWT2

0

2

 

D516V mixed, ΔWT8

S315T1, T2 mixed

A16G mixed

0

2

 

D516V mixed, ΔWT8

S315T1, T2 mixed

-

0

2

 

D516V mixed

S315T1, S315T2

A16G mixed

1

1

 

ΔWT8

S315T1, S315T2

-

0

1

 

ΔWT4

S315T1, S315T2

-

1

0

 

ΔWT8

-

C15T mixed

0

1

 

ΔWT8

S315T1 mixed

-

0

1

 

ΔWT7

-

ΔWT2

0

1

 

ΔWT6, 7, 8

-

ΔWT2

0

1

 

ΔWT1, 6, 8

-

A16G mixed

0

1

 

H526Y

S315T1, S315T2

-

0

1

 

S531L

S315T1, S315T2

C15T

1

0

 

S531L

S315T1, S315T2

-

1

0

 

D516V mixed, S531L

S315T1, T2 mixed

-

1

0

 

D516V mixed, S531L

S315T1, S315T2

A16G mixed

1

0

 

D516V mixed, S531L

-

C15T

0

1

 

S531L

S315T1, S315T2

A16G mixed

0

1

 

S531L

-

A16G mixed

0

1

 

D516V mixed, S531L

S315T1, T2 mixed

A16G mixed

0

1

 

D516V mixed, S531L

S315T2 mixed

-

0

1

 

D516V mixed, S531L

-

A16G mixed

0

1

 

D516V mixed

S315T1, S315T2

-

1

0

 

S531L mixed

S315T1, T2 mixed

A16G mixed, T8A

0

1