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Table 1 Conditions associated with HCV treatment and disease

From: The high comorbidity burden of the hepatitis C virus infected population in the United States

Conditions associated with treatment
Conditions associated with Interferon alfa or Ribavirin use [2]
(see Table 3; denoted by A)
Interferon only:
neutropenia, thrombocytopenia, depression, hypothyroidism and hyperthyroidism, irritability, concentration and memory disturbances, visual disturbances, muscle aches, headaches, nausea and vomiting, low-grade fever, weight loss, insomnia, hearing loss and tinnitus, interstitial fibrosis and hair thinning
Both Interferon and Ribavirin:
skin irritation, fatigue
Ribavirin only:
hemolytic anemia, birth defects and gout
Concurrent disease for which therapy is contraindicated [2]
(See Table 3; denoted by B)
major uncontrolled depressive illness; solid organ transplant (renal, heart, or lung); autoimmune hepatitis or other autoimmune condition known to be exacerbated by peginterferon and ribavirin, untreated thyroid disease; severe concurrent medical disease such as severe hypertension, heart failure, significant coronary heart disease, poorly controlled diabetes and chronic obstructive pulmonary disease
Conditions associated with disease
Symptoms of HCV disease [11]
(see Table 3; denoted by C)
fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, dark urine, clay-colored bowel movements, joint pain and jaundice
Extrahepatic manifestations associated with HCV infection [12]
(see Table 3; denoted by D)
rheumatoid symptoms, keratoconjunctivitis sicca, lichen planus, glomerulonephritis, lymphoma, porphyria cutanea tarda, psychological disorders and essential mixed cryoglobulinemia
Conditions associated with disease progression [2, 13]
(see Table 3; denoted by E)
alcohol use, HIV, HBV and obesity essential hypertension [12] (evidence of reducing HCV disease progression)