Table 2 Unitary costs* and treatment duration parameters used in the model; base-case and sensitivity analysis
Base-case estimate | Sensitivity analysis | |||||
|---|---|---|---|---|---|---|
Deterministic | Probabilistic | |||||
Reference | Reference | Distribution | SD | |||
Total treatment cost per day | ||||||
Posaconazole | 103.69 | 77.77 - 129.61 | Assum. | Gamma | 0.000 | |
Fluconazole | 16.93 | 12.70 - 21.16 | Assum. | Gamma | 0.000 | |
Itraconazole | 21.85 | 16.39 - 27.31 | Assum. | Gamma | 0.000 | |
Drug cost per day | ||||||
Posaconazole | 90.00 | CGCOF[34] | ||||
Fluconazole | 8.00 | CGCOF[34] | ||||
Itraconazole | 8.95 | CGCOF[34] | ||||
Preparation, administration and monitoring treatment cost per day | ||||||
Posaconazole | 13.69 | Gisbert[35] | ||||
Fluconazole | 8.93 | Gisbert[35] | ||||
Itraconazole | 12.90 | Gisbert[35] | ||||
Treatment duration | ||||||
Posaconazole | 29 | Cornely[10] | ||||
Fluconazole | 24 | Cornely[10] | ||||
Itraconazole | 29 | Cornely[10] | ||||
Cost of an invasive fungal infection (IFI) | ||||||
In-patient cost | 67,984 | Grau[36]* | 50,988 - 84,980 | Assum. | Gamma | |