|
Variable
|
Hazard Ratio (95% CI)
|
P Value
|
|---|
|
Prior antibiotic exposure
|
1.473 (1.297-1.672)
|
0.002
|
|
Pulmonary source of infection
|
1.670 (1.496-1.865)
|
<0.001
|
|
APACHE II Score (1-point increments)
|
1.066 (1.057-1.076)
|
<0.001
|
|
Inappropriate antibiotic therapy
|
1.390 (1.239-1.559)
|
0.004
|
|
Hospital-onset infection
|
1.486 (1.234-1.790)
|
0.034
|
|
Pre-culture length of stay (1-day increments)
|
1.012 (0.008-1.016)
|
0.001
|
- CI = confidence interval; APACHE = Acute Physiology and Chronic Health Evaluation
- Other variables included in the analysis for which the Cox-proportional hazards model was adjusted included male gender, age (1-year increments), underlying liver disease, underlying renal disease, underlying malignancy, prior hospitalization (within 90 days), and Charlson co-morbidity score. Hazard ratios greater than 1 indicate the factor is associated with a greater probability of remaining hospitalized. Patients who died were censored at the time of death because they did not reach the endpoint of "discharged alive from hospital."
