Table 1 Baseline Characteristics*
Variable | Prior Antibiotic Exposure (n = 310) | No Prior Antibiotic Exposure (n = 444) | P- value |
|---|---|---|---|
Age (years) | 56.9 ± 16.6 | 60.9 ± 16.0 | 0.001 |
Male | 170 (54.8) | 224 (50.5) | 0.235 |
Infection Onset Type | |||
Community-acquired | 0 (0.0) | 71 (16.0) | <0.001 |
Healthcare-associated community-onset | 30 (9.7) | 236 (53.2) | |
Healthcare-associated hospital-onset | 280 (90.3) | 137 (30.9) | |
Duration of hospitalization prior to sepsis (days) | 20.4 ± 17.1 | 3.2 ± 5.3 | <0.001 |
Underlying Comorbidities | |||
Congestive Heart Failure | 53 (17.1) | 91 (20.5) | 0.243 |
Chronic Obstructive Lung Disease | 62 (20.0) | 74 (16.7) | 0.241 |
Chronic Kidney Disease | 39 (12.6) | 70 (15.8) | 0.221 |
Liver Disease | 37 (11.9) | 57 (12.8) | 0.712 |
Active Malignancy | 95 (30.6) | 146 (32.9) | 0.517 |
Diabetes | 65 (21.0) | 104 (23.4) | 0.426 |
APACHE II score | 23.5 ± 6.5 | 23.8 ± 6.9 | 0.525 |
Charlson co-morbidity score | 4.3 ± 3.7 | 5.2 ± 3.6 | 0.002 |
In ICU when sepsis occurred | 265 (85.5) | 331 (74.5) | <0.001 |
Vasopressors | 207 (66.8) | 234 (52.7) | <0.001 |
Mechanical Ventilation | 221 (71.3) | 196 (44.1) | <0.001 |
Drotrecogin alfa (activated) | 8 (2.6) | 23 (5.2) | 0.077 |
Organ Dysfunction | |||
Cardiovascular | 214 (69.0) | 253 (57.0) | 0.001 |
Respiratory | 238 (76.8) | 228 (51.4) | <0.001 |
Renal | 163 (52.6) | 240 (54.1) | 0.690 |
Hepatic | 24 (7.7) | 31 (7.0) | 0.693 |
Hematologic | 88 (28.3) | 141 (31.8) | 0.322 |
Neurologic | 17 (5.5) | 31 (7.0) | 0.407 |
Number of organ failures | 2.4 ± 1.0 | 2.1 ± 1.1 | <0.001 |
Source of Bacteremia# | |||
Lungs | 166 (53.5) | 134 (30.2) | <0.001 |
Urinary Tract | 67 (21.6) | 163 (36.7) | <0.001 |
Central Venous Catheter | 16 (5.2) | 40 (9.0) | 0.047 |
Intra-abdominal | 64 (20.6) | 73 (16.4) | 0.141 |
Unknown | 8 (2.6) | 41 (9.2) | <0.001 |