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Figure 5 | BMC Infectious Diseases

Figure 5

From: R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes

Figure 5

HIV RNA levels in culture supernatants of monocytes were partially suppressed by R-848 via the TLR7/8 pathway. Monocytes isolated from chronic HIV-infected subjects (n = 9) were cultured in vitro, of which six cases produced detectable low-level viral loads in the culture supernatant. Viral loads of five cases significantly decreased in presence of R-848 (p = 0.0431) and increased in one case. The other three cases had no detectable HIV replication with or without R-848 stimulation. Data was analyzed using the Wilcoxon signed-rank test were used with a level of significance of α = 0.05. All data are expressed as the mean ± SEM from experiments performed in triplicate.

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