Figure 1

Expression of Toll-like receptor 7/8 in peripheral blood monocytes is associated with AIDS progression and correlates positively with CD4 ⁺ cell counts. (A) Expression of TLR7 was significantly increased in slow progressors (SPs) versus uninfected subjects, chronic HIV infected subjects, and subjects with AIDS. TLR7 expression was also significantly increased in subjects with chronic HIV infection versus AIDS. TLR7 in subjects with AIDS was significantly decreased compared to uninfected subjects. The expression of TLR8 was significantly decreased in subjects with AIDS compared with both uninfected subjects and SPs,*p < 0.05. Comparisons were made with one-way ANOVA LSD tests. All data are expressed as the mean ± SEM values from experiments performed in triplicate. (B) The expression of TLR7 and TLR8 was significantly correlated with CD4⁺ cell counts. Data was analyzed using the Spearman rank correlation with a level of significance of α = 0.05.